Bulletin of the American Physical Society
APS March Meeting 2023
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session T06: Mechanics of Cells and Tissues IV
11:30 AM–2:30 PM,
Thursday, March 9, 2023
Room: Room 129
Sponsoring
Unit:
DBIO
Chair: Abdul Malmi Kakkada, Augusta University
Abstract: T06.00001 : Cell division and differential adhesion drive cell self-segregation during embryo morphogenesis.*
11:30 AM–11:42 AM
Presenter:
Xinzhi Li
(Carnegie Mellon University)
Authors:
Xinzhi Li
(Carnegie Mellon University)
Dapeng Bi
(Northeastern University)
Mixing and sorting behaviors in biological systems are central to embryogenesis, tissue regeneration, and cancer growth and metastasis. It is well established that differential interfacial energy between homotypic and heterotypic cells is one of the driving sources that explain cell sorting. However, the complex mechanical interactions involved in typical cell-cell rearrangements are still not well explored. In this work, we use a vertex model to investigate cell segregation during embryogenesis. We find that the self-segregation is naturally driven by the cell division under differential adhesion between different cell types. The cell types differ in division rates which further promote or inhibit sorting behavior depending on the tradeoff between mechanical and chemical feedbacks.
A dynamical vertex model is also used to study the effects of cell motility on sorting. The interesting point is that cell motility could initially enhance the segregation while destroying cell aggregation cluster at large values. It is concluded that the single cell property (mechanical stiffness, motility et al) could also compete with external perturbations (shearing, compression), both of which contribute to shaping the cell segregation patterns.
*NSF DMR-2046683, Alfred P. Sloan Foundation, The Human Frontier Science Program.
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