Bulletin of the American Physical Society
APS March Meeting 2023
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session N10: Cell Fate Transitions
11:30 AM–2:30 PM,
Wednesday, March 8, 2023
Room: Room 202
Sponsoring
Unit:
DBIO
Chair: Jianhua Xing, University of Pittsburgh; Sahand Rahi, Ecole Polytechnique Federale de Lausanne
Abstract: N10.00006 : Single cell dynamics of the Lac operon induction*
12:54 PM–1:06 PM
Presenter:
Louis B Cortes
(Cornell University)
Authors:
Louis B Cortes
(Cornell University)
Guillaume Lambert
(Cornell University)
Collaboration:
We thank members of the Lambert laboratory.
In this work, we designed mother machine devices to directly observe the switch-like behaviour of the lac operon at the single cell level. Our experiments enrich available bulk and single cell population measurements by (1) exploring different growth conditions and (2) providing an extra layer of information that can be directly compared with stochastic simulations.
We show that both stochastic irreversible switching and bi-stable behaviour can be observed in microfluidic chambers depending on the growth conditions. Our quantitative measurements are presented considering recent models and simulations.
*This work was (i) supported by NIH funding under 1R35 GM133759 Maximizing Investigators' Research Award (MIRA) awarded to G.L. and (ii) performed in part at the Cornell NanoScale Facility, an NNCI member supported by NSF Grant NNCI-2025233.
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