Bulletin of the American Physical Society
APS March Meeting 2023
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session N10: Cell Fate Transitions
11:30 AM–2:30 PM,
Wednesday, March 8, 2023
Room: Room 202
Sponsoring
Unit:
DBIO
Chair: Jianhua Xing, University of Pittsburgh; Sahand Rahi, Ecole Polytechnique Federale de Lausanne
Abstract: N10.00011 : Critical growth of cerebral tissue in organoids: theory and experiments*
1:54 PM–2:06 PM
Author not Attending
Presenter:
Egor I Kiselev
(Technion – Israel Institute of Technology)
Authors:
Egor I Kiselev
(Technion – Israel Institute of Technology)
Arndt von Haeseler
(University of Vienna)
Florian Pflug
(Okinawa institute of science and technology)
dividing, asymmetrically dividing and non-dividing) as main agents to study the growth dynamics
of human cerebral organoids. Fitting the theory to lineage tracing data obtained in next generation
sequencing experiments, we show that the growth of cerebral organoids is a critical process. We
derive analytical expressions describing the time evolution of clonal lineage sizes and show how
power-law distributions arise in the limit of long times due to the vanishing of a characteristic
growth scale.
*European Union's Framework Programme for Research and Innovation Horizon 2020 (2014-2020) under the Marie Curie Skªodowska Grant Agreement Nr. 847548Special Research Programme (SFB) of the Austrian Science Fund (FWF), project number F78 P11
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