Bulletin of the American Physical Society
APS March Meeting 2023
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session N08: Synthetic Biology
11:30 AM–1:54 PM,
Wednesday, March 8, 2023
Room: Room 131
Sponsoring
Unit:
DBIO
Chair: Jonathan Michel, Rochester Institute of Technology; Sahand Rahi, Ecole Polytechnique Federale de Lausanne
Abstract: N08.00004 : Atomic Force Microscopy experiment and Monte-Carlo study of the elasticity of exosomes
12:06 PM–12:18 PM
Presenter:
Vikash Pandey
(Nordic Institute of Theoretical Physics)
Authors:
Vikash Pandey
(Nordic Institute of Theoretical Physics)
Hanna Kylhammar
(KTH Royal Institute of Technology)
Vipin Agrawal
(Nordic Institute for Theoretical Physics)
Fredrik Stridfeldt
(KTH Royal Institute of Technology)
Apurba Dev
(KTH Royal Institute of Technology)
Dhrubaditya Mitra
(Nordic Institute for Theoretical Physics)
vesicles (EV) or exosomes, released by the eukaryotic cells, are of great interest.
Their mechanical properties play important roles in their functions, e.g., cellular
uptake of nano-vesicles depend on their deformability. Furthermore, given the
nano-meter size of EVs, thermal fluctuations can renormalise their elastic moduli.
We use Monte-Carlo simulations and Atomic Force Microscopy to study the elastic
properties of exosomes. In particular, we consider two classes of exosomes; i) the
wild type and ii) a special case where expression of Pan protein is artificially
reduced. We show that the exosomes in which the Pan expression is changed is
statistically stiffer compared to wild type. We interpret the data obtained in the
experiments using Monte-Carlo simulations.
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