Bulletin of the American Physical Society
APS March Meeting 2023
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session N06: Cytoskeletal and Cytoplasmic Dynamics and Transport
11:30 AM–2:18 PM,
Wednesday, March 8, 2023
Room: Room 129
Sponsoring
Unit:
DBIO
Chair: Ajay Gopinathan, University of California Merced
Abstract: N06.00006 : Emergent dynamics in motor-free active contractile networks*
12:54 PM–1:06 PM
Presenter:
Xiangting Lei
(Georgia Institute of Technology)
Authors:
Xiangting Lei
(Georgia Institute of Technology)
Tuhin Chakrabortty
(Georgia Institute of technology)
Jerry E Honts
(Drake university)
Saad Bhamla
(Georgia Institute of Technology)
Our results demonstrate that this Ca2+-triggered network exhibits viscoelastic behaviors that under certain conditions can be reversed. We propose a unifying phase diagram for this calcium-driven contractile dynamics. We find that the microscopic parameters, such as diffusion coefficients, control both the morphology and contractility of the macroscopic network in different phases. Based on the simulation, we created a new phase experimentally combing the contractility and maintaining the micro-structure by pulsating energy input.
We demonstrate how this viscoelastic system can be useful in generating controlled active forces and could have potential in an artificial cytoskeletal network in synthetic cells.
* National Science Foundation EF-1935260.
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