Bulletin of the American Physical Society
APS March Meeting 2023
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session K14: Bio-inspired Phase Separation II
3:00 PM–6:00 PM,
Tuesday, March 7, 2023
Room: Room 206
Sponsoring
Units:
DSOFT DPOLY
Chair: Sam Wilken, University of California, Santa Barbara; Omar Saleh, University of California, Santa Barbara
Abstract: K14.00004 : Internal structure in systems of self-coacervating polymers
3:36 PM–3:48 PM
Presenter:
Zuzanna Jedlinska
(University of Pennsylvania)
Authors:
Zuzanna Jedlinska
(University of Pennsylvania)
Robert A Riggleman
(University of Pennsylvania)
essential biological processes, including RNA synthesis, immune and stress
response, and metabolic acceleration. It has also been harnessed to aid in
technological applications such as targeted drug delivery and microencapsulation.
Although charge patterning and hydrophobic interactions have been suggested as
deciding factors in the formation of LLPS and their internal structure, their exact
strength and interplay remains elusive. In this talk, we present the results of our
computational study using a highly coarse-grained polymer model containing
polycation, polyanion, and uncharged blocks with explicit monomer polarizability.
Through systematic variation of monomer polarizability and the arrangement of the
blocks of the copolymer, we show a strong dependence of coacervate stability on
these parameters. We show how uncharged, polar domains can lead to self-
assembled microstructures within the polymer-rich phase. Our results provide
insight into the design of LLPS systems that contain internal structure, which can
help design our own coacervate phases with controllable and fine-tuned phase
behavior.
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