Bulletin of the American Physical Society
APS March Meeting 2023
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session GG09: V: Multicellular Phenomena I
12:30 PM–2:30 PM,
Monday, March 20, 2023
Room: Virtual Room 9
Sponsoring
Unit:
DBIO
Chair: Trung Phan, Yale University
Abstract: GG09.00005 : Computational modelling to predict how extracellular polymeric substances production on biofilm mechanics and detachment*
1:18 PM–1:30 PM
Presenter:
Jinju Chen
(Newcastle University)
Authors:
Jinju Chen
(Newcastle University)
yuqing xia
(Newcastle University)
Jayathilake Pahala Gedara
(University of Oxford)
Bowen Li
(Newcastle University)
Paolo Zuliani
(Newcastle University)
David Deehan
(Freeman hospital)
Jennifer Longyear
(AkzoNobel)
Paul Stoodley
(The Ohio State University)
In this study, a three-dimensional individual-based model (IbM) of biofilm was developed by coupling the computational fluid dynamics approach (CFD) with the discrete element method (DEM). We have modelled a bacterial mutant that can produce the same type of EPS at different levels. Different EPS amount can be obtained by varying the relevant kinetic parameters in the model. We predicted the effect of EPS amount on the mechanical properties of biofilms and biofilm detachment.
*Engineering and Physical Sciences Research Council (EP/K039083/1);BBSRC national Biofilm Innovation Centre (NBIC) (BB/R012415/1|003POC20015)
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