Bulletin of the American Physical Society
2023 APS March Meeting
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session G14: Bio-inspired Phase Separation I
11:30 AM–2:30 PM,
Tuesday, March 7, 2023
Room: Room 206
Sponsoring
Units:
DSOFT DPOLY
Chair: Omar Saleh, University of California, Santa Barbara; Sam Wilken, University of California, Santa Barbara
Abstract: G14.00001 : Biologically-Inspired Active Droplets: from Reaction Crucibles to Robots(?)
11:30 AM–12:06 PM
Presenter:
Eric R Dufresne
(ETH Zurich)
Author:
Eric R Dufresne
(ETH Zurich)
In the last decade, we have come to appreciate that cells alternatively use the spontaneous phase separation of macromolecules to compartmentalize chemical reactions. This approach to encapsulation, based on thermodynamics, is robust and easy to implement. Here, I will introduce a very simple and flexible model system for creating droplets of protein that readily partition enzymes, and allow for easy exchange of substrate and product with their surroundings. I will quantify their ability to localize chemical reactions, and demonstrate their ability to sense and respond to external chemical gradients - a type of rudimentary chemotaxis.
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