Bulletin of the American Physical Society
APS March Meeting 2023
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session G11: Multi-Scale Modelling of Biological Cells: from Atoms to Whole Cells
11:30 AM–2:30 PM,
Tuesday, March 7, 2023
Room: Room 203
Sponsoring Unit: DBIO
Chair: Margaret Cheung, Pacific Northwest National Laboratory
Abstract: G11.00004 : Landscapes of Genomic Architecture Across Evolution
12:30 PM–1:06 PM
Michele Di Pierro
Michele Di Pierro
In this talk, I will demonstrate how the architecture of interphase chromosomes is encoded in the one-dimensional sequence of epigenetic markings much as three-dimensional protein structures are determined by their one-dimensional sequence of amino acids. In contrast to the situation for proteins, however, the sequence code provided by the epigenetic marks that decorate the chromatin fiber is not fixed but is dynamically rewritten during cell differentiation, modulating both the three-dimensional structure and gene expression in different cell types.
This idea led to the development of a physical theory for the folding of genomes, which enables predicting the spatial conformation of chromosomes with unprecedented accuracy and specificity. Finally, I will demonstrate how the different energy terms present in our model impact the topology of chromosomes across evolution. Our results open the way for studying functional aspects of genome architecture along the three of life.
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