Bulletin of the American Physical Society
APS March Meeting 2023
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session D15: Polymer Gels
3:00 PM–6:00 PM,
Monday, March 6, 2023
Room: Room 207
Sponsoring
Unit:
DPOLY
Chair: Gabriel Sanoja, The University of Texas at Austin
Abstract: D15.00014 : Structural relaxation of dynamic formation of clustering within a extracellular matrix, a simulation model of articular cartilage*
5:36 PM–5:48 PM
Presenter:
Alexandros Chremos
(National Institutes of Health - NIH)
Authors:
Alexandros Chremos
(National Institutes of Health - NIH)
Jack F Douglas
(National Institute of Standards and Tech)
Peter J Basser
(NIH)
Ferenc Horkay
(National Institutes of Health - NIH)
Articular cartilage is a composite hydrogel found in animal and human joints, which exhibits unique load-bearing properties that have been challenging to reproduce in synthetic materials and model in molecular dynamics (MD) simulations. We developed a coarse-grained model of a composite hydrogel as a biomimetic model to investigate its unique load-bearing properties. Our composite gel model is composed of an extracellular covalently bonded polymeric matrix and small polymeric particles embedded in the polymer matrix. We find the formation of a dynamic network formed by the embedded particles within the polymer matrix and it is associated with the emergence of prestress in this gel-type of materials. The prestress plays a key role in enhancing the mechanical and load-bearing properties of the gel materials. Our MD simulations of the development of prestress agree semi-quantitatively with osmotic pressure measurements observed in our model composite hydrogel material.
*This research was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH.
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