Bulletin of the American Physical Society
APS March Meeting 2023
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session D06: Mechanics of Cells and Tissues II
3:00 PM–6:00 PM,
Monday, March 6, 2023
Room: Room 129
Sponsoring
Unit:
DBIO
Chair: Ming Guo, MIT
Abstract: D06.00006 : Vertex Modeling of Epithelial Tissues: Structural Changes from Out-of-plane Mechanics*
4:24 PM–4:36 PM
Presenter:
Mayisha Z Nakib
(University of Illinois at Urbana-Champaign)
Authors:
Sascha Hilgenfeldt
(University of Illinois at Urbana-Champaign)
Mayisha Z Nakib
(University of Illinois at Urbana-Champaign)
Jairo Martin Rojas HuamanĂ
(University of Illinois Urbana-Champaign)
William Brieher
(University of Illinois at Urbana-Champaign)
We show here that the quantitative predictions of a two-dimensional approach fail to agree with experimental data on MDCK epithelia, predicting floppy mechanics where the tissues are stable and rigid. We identify the cause of this discrepancy as the presence of actin stress fiber bundles near the basement membrane, breaking the apical-basal symmetry and leading to significant, systematic changes in cell outline as a function of the apical-basal coordinate. The main effect on average cell shape is increased anisotropy related to the orientation of the fiber bundle. A modified 2D vertex model calibrates the strength of the effect on cell shape with the fiber bundle strength and correlates the bundle orientation and cell anisotropy orientation with the mechanical energy of the system, thus restoring the viability of diagnosing tissue mechanics from visual information only.
*We acknowledge funding under Grant # 60050530 from the NSF-Simons Center for Quantitative Biology at Northwestern University
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