Bulletin of the American Physical Society
APS March Meeting 2023
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session B06: Mechanics of Cells and Tissues I
11:30 AM–2:30 PM,
Monday, March 6, 2023
Room: Room 129
Sponsoring
Unit:
DBIO
Chair: Moumita Das, Rochester Institute of Technology
Abstract: B06.00004 : Measuring the Variability in Individual Fibrin Fiber Mechanics by AFM*
12:06 PM–12:18 PM
Presenter:
Christine Helms
(University of Richmond)
Author:
Christine Helms
(University of Richmond)
Lateral force atomic force microscopy was used to measure fiber extensibility, the force required for fiber failure, and force-strain curves. Data was obtained for fibers formed with 0.1 mg/ml, 1 mg/ml, and 2 mg/ml of fibrinogen (Fgn). The data was split into two groups based on the mean and median values for the initial slope of the force-strain curve. Fibers formed with 0.1 mg/ml Fgn fell in the group with a lower initial slope and fibers formed with 2 mg/ml Fgn fell in the group with a higher initial slope, those formed with 1 mg/ml Fgn fell into both groups.
Softer fibers, those with a lower initial slope, ruptured at a lower force but they extended further than their counterparts with a larger slope. Fibrin fibers are reported to undergo an increase in the slope of their force-strain curve around 100 % strain. The data showed softer fibers extended further before their slope changed, to an average strain of 150 %. Fibers with an initially steep slope increased their slope at an average strain of 55 %. While these data are preliminary (n = 15 fibers), they provide insight into the variability of fibrin fiber mechanics and lead to questions about the mechanisms responsible for the variability.
*University of Richmond - Summer Research Fellowship
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