Bulletin of the American Physical Society
APS March Meeting 2022
Volume 67, Number 3
Monday–Friday, March 14–18, 2022; Chicago
Session Z07: Novel Instrumentation
11:30 AM–2:30 PM,
Friday, March 18, 2022
Room: McCormick Place W-179A
Sponsoring
Unit:
DBIO
Chair: Shubham Tripathi, Rice University
Abstract: Z07.00006 : Biocompatible surface functionalization architecture for a diamond quantum sensor*
12:30 PM–12:42 PM
Presenter:
Mouzhe Xie
(The University of Chicago)
Authors:
Mouzhe Xie
(The University of Chicago)
Xiaofei Yu
(University of Chicago)
Lila Rodgers
(Princeton University)
Daohong Xu
(The University of Chicago)
Ignacio Chi Durán
(The University of Chicago)
Adrien Toros
(EPFL)
Niels Quack
(EPFL)
Nathalie P de Leon
(Princeton University)
Peter Maurer
(The University of Chicago)
Here, we introduce a general strategy to tackle this challenge. A thin layer of alumina is uniformly laid on diamond surface by atomic layer deposition, which is then passivated with functional polyethylene glycol (PEG) molecules. The functional PEG layer recruits target molecules via highly specific interactions, such as biotin-streptavidin interaction and strain-promoted azide-alkyne cycloaddition “click chemistry”, while greatly reducing nonspecific binding. This allows us to position target molecules within 5 nm distance from the diamond surfaces. The grafting density can be precisely controlled by tuning the composition of PEG molecules, and the functionalization is stable over days under physiological conditions. The impact of this functional layers on the spin coherence properties of NV centers is found to be minimal, with only about 15% reduction in T2 and negligible change in T1. This method should lay a solid foundation for NV-based single-molecule electron paramagnetic resonance (EPR) or nuclear magnetic resonance (NMR) experiments on a variety of biomolecules, which will deepen our mechanistic understanding of their biological functions.
*We thank NSF and the Swiss National Science Foundation for funding supports. We acknowledge the use of PNF and MRSEC research facilities at the University of Chicago, and the Imaging and Analysis Center at Princeton University.
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