Bulletin of the American Physical Society
APS March Meeting 2022
Volume 67, Number 3
Monday–Friday, March 14–18, 2022; Chicago
Session Y04: Collective Behaviors in Biology II
8:00 AM–10:00 AM,
Friday, March 18, 2022
Room: McCormick Place W-176C
Sponsoring
Unit:
DBIO
Chair: Brian Camley, Johns Hopkins University
Abstract: Y04.00007 : A Celluar Potts Model for Collective Cell Migration
9:12 AM–9:24 AM
Presenter:
Man Ho Tang
(University of California, San Diego)
Authors:
Man Ho Tang
(University of California, San Diego)
Wouter-Jan Rappel
(University of California, San Diego)
Stephanie Fraley
(University of California, San Diego)
William Leineweber
(University of California, San Diego)
Sural Ranamukhaarachchi
(University of California, San Diego)
Alyssa Walker
(University of California, San Diego)
Here, we present two applications of the Cellular Potts Model (CPM) to describe different collective migration patterns that are experimentally observed: 1) coherent rotational motion during aggregation of social amoeba Dictyostelium discoideum cells and, 2) distinct invasion modes of cancer cells embedded in extracellular matrix (ECM). In these examples, we show that the CPM can produce results that qualitatively and quantitatively match experimental results. Furthermore, we show that by perturbing model parameters, we are able to explore a variety of migration modes and make experimentally testable predictions.
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