Bulletin of the American Physical Society
APS March Meeting 2022
Volume 67, Number 3
Monday–Friday, March 14–18, 2022; Chicago
Session W05: Ecological and Evolutionary Dynamics V
3:00 PM–6:00 PM,
Thursday, March 17, 2022
Room: McCormick Place W-178A
Sponsoring Unit: DBIO
Chair: Daniel Weissman, Emory
Abstract: W05.00008 : Hybridization driven by selection is a major source of genetic diversity in a natural bacterial population*
4:48 PM–5:00 PM
(Carnegie Institution for Science)
Daniel S Fisher
To address this question, we used single cell genomics to sequence a large, unbiased sample from a population of thermophilic cyanobacteria. Consistent with previous results, we find that coarse genomewide measures of diversity suggest the population comprises two main, highly distinct, sequence clusters . Despite this, diversity patterns on finer scales are fundamentally incompatible with the view that clusters represent distinct species with recombination mainly limited to closely-related cells. Instead, we find evidence that selection leads to extensive hybridization between highly diverged strains on genome scales ranging from tens to thousands of base pairs. These results suggest that hybridization may play a major and previously unrecognized role in maintaining diversity in bacterial populations.
*G.B. was supported by the Simons Foundation Postdoctoral Fellowship Award 730295. G.B. and D.S.F. acknowledge support from NSF Grant PHY-1607606. D.B. acknowledges support from NSF Grant #1921429 and JGI-CSP Grant #503441.
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