Bulletin of the American Physical Society
APS March Meeting 2022
Volume 67, Number 3
Monday–Friday, March 14–18, 2022; Chicago
Session T07: The Physics of Cell Membranes II: From Simplified Models to Complex Functionality
11:30 AM–2:18 PM,
Thursday, March 17, 2022
Room: McCormick Place W-179A
Sponsoring Unit: DBIO
Chair: Rana Ashkar, Virginia Tech
Abstract: T07.00010 : How pinning influences the dynamics of cell membranes*
1:42 PM–1:54 PM
(a) for small frame tension the internal tension decreases as pinning increases,
(b) The internal tension and the fluctuating tension are approximately equal,
(c) how the pinned points are distributed affects the spectrum at small wavenumbers but has no significant effect on the internal tension.
Assuming small deformation we derive, theoretically, how the change in area varies with change in surface tension for a pinned membrane. This agrees with our simulations. We use flicker imaging of HeLA cells to probe the same relation experimentally while we turn off the pinning of the cell membrane (partially) to the cytoskeleton by manipulating the protein ezrin. Results of these experiments agree with both theory and numerical simulations showing that dynamics of the cell membrane is dominated by its pinning to the cytoskeleton.
The American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics.
1 Physics Ellipse, College Park, MD 20740-3844
Editorial Office 1 Research Road, Ridge, NY 11961-2701 (631) 591-4000
Office of Public Affairs 529 14th St NW, Suite 1050, Washington, D.C. 20045-2001 (202) 662-8700