Bulletin of the American Physical Society
APS March Meeting 2022
Volume 67, Number 3
Monday–Friday, March 14–18, 2022; Chicago
Session T00: Poster Session III (1pm- 4pm CST)
1:00 PM,
Thursday, March 17, 2022
Room: McCormick Place Exhibit Hall F1
Abstract: T00.00344 : Disentangling Intracellular Behavior from Extracellular Data*
Presenter:
Andre Archer
(Northwestern University)
Authors:
Andre Archer
(Northwestern University)
Taylor Nichols
(Northwestern University)
Niall Mangan
(Northwestern University)
Danielle Tullman-Ercek
(Northwestern University)
With published consumption and production time series data of bacteria feeding on different initial glycerol concentrations, I used Bayesian inference on a differential equation model of the system to infer the unknown parameters. The resulting data distribution closely matched the experimental results. The resulting parameter distributions revealed that glycerol and 1,3-PDO are transported via facilitated diffusion; the maximum reaction rate of DhaT is larger in-vivo than in-vitro; and the permeability of 3-HPA, a toxic intermediate, is structurally unidentifiable under the experimental conditions.
*Department of Energy, Office of Sciences
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