Bulletin of the American Physical Society
APS March Meeting 2022
Volume 67, Number 3
Monday–Friday, March 14–18, 2022; Chicago
Session S06: Biomolecular Phase Separation I - Interactions, Thermodynamics and Mechanics
8:00 AM–10:48 AM,
Thursday, March 17, 2022
Room: McCormick Place W-178B
Sponsoring
Units:
DBIO DSOFT
Chair: Patrick McCall, Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Abstract: S06.00012 : Computational design of amino-acid sequence variations that modulate the liquid-liquid phase separation of intrinsically disordered proteins*
10:36 AM–10:48 AM
Presenter:
Maria J Maristany
(Univ of Cambridge)
Authors:
Maria J Maristany
(Univ of Cambridge)
Jerelle A Joseph
(University of Cambridge)
Rosana Collepardo-Guevara
(University of Cambridge)
Aleks Reinhardt
(University of Cambridge)
[1] Joseph, Reinhardt et al., Physics driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy, Nat. Comput. Sci., 2021 (in press).
[2] Bremer et al, Deciphering how naturally occurring sequence features impact the phase behaviors of disordered prion-like domains, bioRxiv, 2021.
[3] Lichtinger et al, Targeted modulation of protein liquid–liquid phase separation by evolution of amino-acid sequence, Plos CompBiol, 2021
*This project received funding from the ERC under the European union's Horizon 2020 research and innovation programme (grant No803326) and has been performed using resources provided by the Cambridge Tier-2 system operated by the UoC Research ComputingService, funded by EPSRC Tier-2 capital grant EP/P020259/1. M.J.M. is a scholar of the Winton Programme for the Physics of Sustainability. J.A.J. is a Research Fellow at King's College.
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