Bulletin of the American Physical Society
APS March Meeting 2022
Volume 67, Number 3
Monday–Friday, March 14–18, 2022; Chicago
Session M13: Physics-Enabled Medical Devices and TechnologyIndustry Invited Live Streamed Undergrad Friendly
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Sponsoring Units: GMED FIAP Chair: Stephen Russek, NIST Boulder Room: McCormick Place W-183A |
Wednesday, March 16, 2022 8:00AM - 8:36AM |
M13.00001: Microwave Microfluidic Spectroscopy for Biomolecular Measurements in Solution Invited Speaker: Angela C Stelson Communications technology is playing an increasing role in biotechnology and medicine in the form of wearable, implantable, and diagnostic devices. To advance these applications, industry requires quantitative measurements of the electrical properties of biological systems. Here, I will present a range of applications of broadband quantitative electrical measurements in biotechnology, including label-free detection of biomolecules in solution. As an example of this approach, I will present an on-chip, label-free technique to detect conformational changes in a DNA nanomechanical tweezer structure with microwave microfluidics. Through a combination of calibration techniques, we are able to achieve broadband electrical measurements from 40 kHz to 110 GHz, and extract equivalent circuit elements associated with the tweezer opening in solution. Microwave microfluidics is a generalizable, non-destructive technique, making it attractive for high-throughput measurements for medical diagnostics and pharmaceutical development. |
Wednesday, March 16, 2022 8:36AM - 9:12AM |
M13.00002: Eavesdropping on Neuronal Chemical Chatter Using SWIR emissive Optical Nanosensors Invited Speaker: Abraham Gusu Beyene Neurons communicate through chemical signaling molecules that may diffuse beyond their point of release and modulate the activity of larger neuronal networks, in a process known as volume transmission. Molecules such as dopamine belong to this class of diffusive neurotransmitters, for which real-time imaging of the signal's spatial propagation would constitute a major advance in neurochemical imaging. To this end, we present a nanoscale, short-wave infrared (SWIR) fluorescent optical reporter for dopamine and demonstrate its efficacy for imaging dopamine volume transmission. The sensor is synthesized from single wall carbon nanotubes (SWCNT) functionalized with single-strand DNA oligonucleotides and fluoresces in the tissue compatible SWIR window at 1000-1300 nm. We demonstrate that these sensors exhibit remarkable robustness that enables them to be immobilized on glass substrates for extended periods of time, on which primary dopaminergic neurons can be cultured. In this preparation, we show that our sensor-functionalized coverslips can detect synaptic dopamine efflux with remarkable spatial and temporal resolution, at length and time scales that elude conventional methods of inquiry. Our results show that SWCNT-based SWIR emissive nanosensors can relay information about neuronal signaling in a tissue-compatible optical window and constitute a versatile class of synthetic optical tools for applications in the life sciences. |
Wednesday, March 16, 2022 9:12AM - 9:48AM |
M13.00003: Magnetic Resonance Imaging of the Human Brain at the Bedside Invited Speaker: Megan Poorman Hyperfine, Inc. is a medical imaging company that created and markets an FDA-cleared portable MRI intended for brain imaging at the patient's bedside in a variety of clinical settings. The device can be wheeled directly to the patient's bedside, plugged into a standard electrical wall outlet, and can acquire critical images of a patient's brain without requiring transport within the hospital. This represents a breakthrough in accessibility for MRI. This is made possible by using advanced magnetic resonance acquisition techniques (including electromagnetic interference removal) and reconstruction algorithms (including deep learning). This talk will describe the design challenges and our solution to creating a physics-based system that can be used in real-world medical settings. |
Wednesday, March 16, 2022 9:48AM - 10:24AM |
M13.00004: Invited Talk: Thomas Cull Invited Speaker: Thomas Cull
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Wednesday, March 16, 2022 10:24AM - 11:00AM |
M13.00005: Benchtop permanent-magnet NMR at 3 T for biomedical and hyphenated applications Invited Speaker: John C Price Permanent magnets have been a part of NMR spectroscopy since its inception. Massive floor-standing permanent magnets at 1.4 T and 2.2 T first became common in the 1970’s, especially in chemical education. A revolution in the field began in the late 2000s, with the introduction of self-contained benchtop permanent-magnet spectrometers that exploit modern developments in rare-earth hard ferromagnets, low-noise analog RF electronics, FPGA-based digital signal processing, and real-time software control. While not as powerful as their high-field counterparts, the small size, low mass, and low cost of these instruments has opened up many new application areas for NMR. In this talk, I will describe a new design that raises the upper field limit for benchtop NMR to 2.94 T, corresponding a 125 MHz proton Larmor frequency. Our new spectrometer is a compact instrument with a total mass of 28 kg, and it is adapted to automated applications where the sample fluid is delivered by flow, rather than in an NMR tube. Applications include biomaterials, pharmaceuticals, forensics and hyphenation with separation techniques. The design of these instruments is highly physics-enabled, with contributions from every major subject area in a typical university physics curriculum. |
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