Bulletin of the American Physical Society
APS March Meeting 2022
Volume 67, Number 3
Monday–Friday, March 14–18, 2022; Chicago
Session D42: Biomolecular Solution Assembly
3:00 PM–6:00 PM,
Monday, March 14, 2022
Room: McCormick Place W-375A
Sponsoring
Unit:
DPOLY
Chair: Darrin Pochan, University of Delaware
Abstract: D42.00002 : Self-assembly of Helical Peptide Filaments and Tubes*
3:36 PM–4:12 PM
Presenter:
Vincent Conticello
(Emory University)
Author:
Vincent Conticello
(Emory University)
Structural studies of synthetic peptides and proteins provide the best opportunity to create analogues of biologically derived protein filaments to understand the sequence-structure relationship that underlies the the self-assembly process and, ultimately, functional properties. However, the structures of most designed peptide assemblies are not known at high resolution and reliable structural models are not available. Here, we report the cryo-EM analysis of designed peptide assemblies that enables the reconstruction of reliable atomic models. These structural analyses suggest that polymorphism is a common occurrence among designed peptide assemblies. In addition, chaotic behavior is commonly observed in which the observed structure depends strongly on initial conditions. In addition, sequence-structure correlations derived from the analysis of soluble, globular proteins provide limited predictive insight into the reliable design of filamentous peptide nanomaterials. Therefore, high-resolution structural analyses of native and synthetic assemblies are essential to build databases that can be employed as a resource of information to guide reliable structural prediction and sequence design of self-assembling peptides.
*NSF grant DMR-1534317
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