Bulletin of the American Physical Society
APS March Meeting 2022
Volume 67, Number 3
Monday–Friday, March 14–18, 2022; Chicago
Session D05: Morphogenesis I
3:00 PM–5:36 PM,
Monday, March 14, 2022
Room: McCormick Place W-178A
Sponsoring
Units:
DBIO GSNP DSOFT
Chair: Andrej Kosmrlj, Princeton
Abstract: D05.00002 : Large-scale cortex-core structure formation in brain organoids*
3:36 PM–3:48 PM
Presenter:
Ahmad Borzou
(Baylor University)
Authors:
Ahmad Borzou
(Baylor University)
J. M Schwarz
(Syracuse University)
J. M Schwarz
(Syracuse University)
diversity. However, do they recapitulate
brain shape? Using a hydrodynamic description for cell nuclei
as particles interacting via an attractive field generated by the
surrounding active cell
cytoskeleton, we quantify shape development in brain
organoids. Regions of cell nuclei overdensity in the linear regime drive the initial
seeding for cortex-core structures, which emerge in the non-linear regime with
elongated cell nuclei and thus, cell shape, in the cortex. We then use
an extended version of the buckling without
bending morphogenesis model to predict foliations/folds of the
cortex in the presence of a nonlinearity due to elongated cells actively
regulating strain. In addition to laying new groundwork for the design
of more familiar and less familiar brain shapes, our work provides an intriguing
quantitative connection with large-scale structure formation in the universe.
*JMS acknowledges financial support from NSF-DMR-1832002 and an Isaac Newton Award from the DoD.
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