Bulletin of the American Physical Society
APS March Meeting 2022
Volume 67, Number 3
Monday–Friday, March 14–18, 2022; Chicago
Session A04: Synthetic Biology I
8:00 AM–10:48 AM,
Monday, March 14, 2022
Room: McCormick Place W-176C
Sponsoring
Units:
DBIO GSNP
Chair: Gábor Balázsi, Stony Brook University
Abstract: A04.00002 : Metabolic Pathway Design Using Active Subspaces*
8:12 AM–8:24 AM
Presenter:
Andre Archer
(Northwestern University)
Authors:
Andre Archer
(Northwestern University)
Taylor Nichols
(Northwestern University)
Niall Mangan
(Northwestern University)
Danielle Tullman-Ercek
(Northwestern University)
To rank the strains, I considered quantities of interest (QoIs): product yield, rate of production and toxicity level. Evaluating QoIs on uniformly sampled parameters, restricted by physical constraints and prior measurements, is computationally intractable. To efficiently generate value ranges for each QoI, I used Active Subspaces to identify parameter directions that most affect each QoI. I then used maximin sampling to produce a space-filling spread of parameter samples in the significant parameter directions while randomly perturbing the samples in the insignificant directions. This sampling reduced the computational load by at most 5 orders of magnitude when compared to a coarse grid sampling. The QoI distributions converged with increasing numbers of samples. I used hypothesis testing on the QoI distributions to predict optimal producing strains.
*Department of Energy, Office of Sciences
Follow Us |
Engage
Become an APS Member |
My APS
Renew Membership |
Information for |
About APSThe American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics. |
© 2025 American Physical Society
| All rights reserved | Terms of Use
| Contact Us
Headquarters
1 Physics Ellipse, College Park, MD 20740-3844
(301) 209-3200
Editorial Office
100 Motor Pkwy, Suite 110, Hauppauge, NY 11788
(631) 591-4000
Office of Public Affairs
529 14th St NW, Suite 1050, Washington, D.C. 20045-2001
(202) 662-8700