Bulletin of the American Physical Society
APS March Meeting 2020
Volume 65, Number 1
Monday–Friday, March 2–6, 2020; Denver, Colorado
Session D28: Metrology in Medical ImagingIndustry Invited
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Sponsoring Units: GMED FIAP Room: 405-407 |
Monday, March 2, 2020 2:30PM - 3:06PM |
D28.00001: Introduction to quantitative imaging Invited Speaker: Timothy Hall The standard paradigm in medical imaging uses sophisticated imaging systems that take advantage of a variety of phenomena that create image contrast, and those images are subjectively interpreted by highly trained clinicians. The trend toward measurement-driven medicine motivates an effort to convert imaging systems into measurement systems which provide quantitative imaging biomarkers. The mission of the Radiological Society of North America’s Quantitative Imaging Biomarker Alliance is to improve the value and practicality of quantitative imaging biomarkers by reducing variability across devices, sites, patients, and time. The core of the effort is the adoption of the principles of metrology into image analysis methods so confidence intervals can be claimed on imaging/measurement performance. Physicists’ contribution to this effort includes developing new imaging biomarkers, creating simulations of the physical interactions of image formation (in silico phantoms), and creating methods for objectively quantifying the technical performance of the system. Examples of objectively assessed parameters that are direct substitutes for subjectively assessed parameters, as well as other parameters that are not readily extracted from standard imaging methods, will be described. Methods for assessing their performance as quantitative imaging biomarkers will be described. |
Monday, March 2, 2020 3:06PM - 3:42PM |
D28.00002: Importance of Statistical Metrology Framework for Quantitative Imaging Applications Invited Speaker: Nancy Obuchowski Quantitative imaging is being increasingly used to diagnose disease, predict patients’ outcomes, and monitor and adapt treatment. In clinical trials, quantitative imaging often serves as a non-invasive endpoint which can provide results earlier than traditional patient outcomes. |
Monday, March 2, 2020 3:42PM - 4:18PM |
D28.00003: Quantitative Imaging Applications for Radiography and Computed Tomography Invited Speaker: Sam Armato Post-acquisition mathematical analysis of medical images can range from simple image processing to complex computer-aided diagnosis. The intent of such manipulation can range from the enhancement of aspects of the image for improved human visualization to artificial intelligence. The tools available for image analysis span the fields of mathematics, statistics, and computer science and incorporate biophysical aspects of the medical image acquisition system. The extraction of quantitative information (or “features”) from medical images and the use of this information to assist radiologists in their medical decision-making process (termed “radiomics”) has expanded medical imaging from a subjective art to much more of an objective science. Radiography, as the most common imaging modality, and computed tomography (CT), as the predominant tomographic imaging modality, both benefit from a vast array of quantitative techniques. Applications include volumetry of tumors and other abnormalities, assessment of response to therapy, patient prognosis, and evaluation of disease severity. |
Monday, March 2, 2020 4:18PM - 4:54PM |
D28.00004: PET/CT and PET/MR quantitative imaging applications Invited Speaker: Anne Smith Due to its unique physical decay properties, positron emission tomography (PET) was developed, commercialized and marketed as a quantitative imaging technique. The first commercial scanners sold in the 1970s targeted the clinical research market, in particular for neurology and cardiology applications. The 1980s saw the rapid development of a new PET tracer called 18-F fludeoxyglucose (FDG), which is an effective tracer to quantitatively measure absolute glucose metabolism (e.g. umol of glucose/min/100 gm of tissue) non-invasively. It was soon shown that FDG PET filled an unmet clinical need for both the diagnosis and treatment of cancer patients, and the 1990s saw a rapid growth of clinical PET. PET innovations in the 2000s included whole body PET scans (e.g. moving the patient bed so patients can be scanned from head to toes), and the hybridization of PET scanners with CT and MR for better anatomical location. Today, 95% of all clinical PET scans are whole body FDG oncology scans. However, in order to make the scan time shorter and the analysis and reading faster, surrogate measures of absolute glucose metabolism were developed. The most popular surrogate is the standardized uptake value (SUV), and this talk will cover the pros and cons of using the SUV as a quantitative measure and initiatives driven by PET physicists and clinicians to make it a better universal and quantitative measure. The latest quantitative PET innovations from industry will also be presented, including making the measure of absolute glucose metabolism practical in the clinic – effectively bringing PET full circle and back to its commercial beginnings. |
Monday, March 2, 2020 4:54PM - 5:30PM |
D28.00005: Better Medicine through Measurement: Developments and Applications of Quantitative Magnetic Resonance Imaging Invited Speaker: Michael Boss Magnetic Resonance Imaging (MRI) is able to interrogate a wide range of physical parameters. Some of these are intrinsic to magnetic resonance, such as relaxation times, whiles others are universal, such as diffusion coefficients, temperature, or magnetic susceptibility. This talk will provide an overview of important quantitative imaging biomarkers (QIBs) in MRI, highlighting their current and future applications, the challenges in measurement science and implementation, and the current status and progress of QIBs towards widespread clinical adoption. |
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