Bulletin of the American Physical Society
75th Annual Gaseous Electronics Conference
Volume 67, Number 9
Monday–Friday, October 3–7, 2022;
Sendai International Center, Sendai, Japan
The session times in this program are intended for Japan Standard Time zone in Tokyo, Japan (GMT+9)
Session EF2: Plasma Medical & Agricultural Application II |
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Chair: Nevena Puac, Institute of Physics Belgrade Serbia Room: Sendai International Center Hagi |
Friday, October 7, 2022 10:00AM - 10:30AM |
EF2.00001: Plasma-based in situ functionalization based on functional nitrogen science Invited Speaker: Kenji Ishikawa Functional nitrogen science is now emerged for effective utilization of reactive nitrogen species (RNS). The technologies are related to water and air plasma-based nitrogen fixation. Electron impact reactions and chemical reactions among nitrogen, oxygen, and hydrogen, can occur on non-equilibrium plasma processing. Key issues are on in situ generation of RNS at the point of use and plasma-based nitrogen cycles of ammonia and nitric acid. |
Friday, October 7, 2022 10:30AM - 10:45AM |
EF2.00002: Plasma Activated Water Developments for Lunar and Martian Applications Ryan P Gott, Kenneth Engeling, Joel Olson, Carolina Franco, Christina Johnson, Mary Hummerick Plasma activated water (PAW) could be of great use for space applications, due to the myriad of on-demand uses. The presence of any nitrogen in the gas stream, including in a simulated Martian atmospheric composition, allows for nitrates to form in water during plasma treatment. These nitrates form nitric acid and drive down the pH while also being in a readily useable form by plants. By varying the reactions and mixing in natural additives, pH values from 2.7 to 11.5 were achieved. The pH control allows for use with many different plant species. This methodology is also enabling for space-based hydroponic systems. Growth studies of Cherry Belle radishes showed comparable dry masses of edible biomass grown with Hoagland’s nutrient solution (a best-case scenario solution that is impractical for launch transportation) and the edible biomass grown with PAW. Both solutions showed substantial improvements over the deionized water that is most similar to what is available in Space systems via the water processor assembly. Additionally, the ability to produce both acidic PAW and basic PAW has benefits for sanitation as well. Preliminary studies showed a 5.8 log reduction of P. Aeruginosa when exposed to PAW mixtures, which shows the ability to remove this common biofilm. |
Friday, October 7, 2022 10:45AM - 11:00AM |
EF2.00003: Influence of COST-Jet produced Short-lived RONS on Cellular Responses Maria J Herrera Quesada, Cameron Wagoner, Katharina Stapelmann Non-thermal plasma (NTP) has been shown to be a promising technique for the treatment of cancer due to its ability to create a strong immunostimulatory response through the controlled delivery of reactive oxygen and nitrogen species (RONS). However, NTP mechanisms to produce these effects are not yet fully elucidated. |
Friday, October 7, 2022 11:00AM - 11:15AM |
EF2.00004: Effective Area of Relatively Short-lived Reactive Oxygen Species Generated by Atmospheric-pressure Helium Microplasma Jet Jun-Seok Oh, Yuta Matsumoto, Shunya Hashimoto, Tatsuru Shirafuji Here we investigated effective area of relatively short-lived reactive oxygen species (ROS), i.e., OH radicals and / or singlet oxygen (1O2), generated by an atmospheric-pressure helium microplasma jet. Discoloration of methylene blue solution in a 3D printed micro-well was used for evaluation of the effect of short-lived ROS. It was confirmed that there are no discoloration with longer-lived ROS and RNS. Our experimental results show that short-lived ROS can be affected a large area about 16 mm in diameter. |
Friday, October 7, 2022 11:15AM - 11:30AM |
EF2.00005: Influence of Skin Temperature Increase During Helium Plasma Jet Irradiation Shunya Hashimoto, Yuta Matsumoto, Tatsuru Shirafuji, Hideo Fukuhara, Chiaki Kawada, Keiji Inoue, Masayuki Tsuda, Endre J Szili, Jun-Seok Oh In recently, atmosphere pressure plasma jet (APPJ) has been widely applied to the research field of life science, because APPJ can generate reactive species. For effective use of the plasma, there is needs to deliver the reactive species into biological targets e.g., cell and / or tissue. In our previous collaborative studies, we have shown how plasma generated reactive species are delivered into solid tumor underneath skin. Interestingly, we observed unusual skin condition after a long-term direct plasma irradiation in another unpublished study. We speculated such unusual skin condition is due to increase of skin temperature during plasma irradiation. Aim of this study is how the unusual skin condition to be formed from the point of view of surface skin temperature. In this study, we used live nude mouse, mouse skin (or chicken skin) and 3D printed mouse model for irradiation targets. We investigated correlation between increase of surface temperature on the skin and plasma bullet current. These results indicate that the increase in skin surface temperature during plasma irradiation is due to the current of the plasma bullets. Also, we estimated possible burn area from experiment result. However, as a conclusion, the possibility of burns was ruled out from our pathology results. |
Friday, October 7, 2022 11:30AM - 11:45AM |
EF2.00006: Biological effects of the combination with low temperature plasmas and nanoparticles-platinum and gold- Kenji Ishikawa, Takashi Kondo, Hiromasa Tanaka, Masaru Hori, Shinya Toyokuni, Masaaki Mizuno Interaction between low temperature plasmas (LTP) and nanoparticles is an interesting topic. Platinum nanoparticles (Pt-NPs) are potent antioxidants due to their unique ability to scavenge superoxides and peroxides. First, the effects of Pt-NPs on He-LTP-induced apoptosis and the underlying mechanism were examined in human lymphoma U937 cells. The results indicate that Pt-NPs substantially scavenge LTP-induced ROS and inhibit all the pathways involved in apoptosis execution. Second, gold nanoparticles (Au-NPs) have attracted attention as a promising radiosensitizer owing to their high atomic number. Here, the activity of different sized Au-NPs with He-LTP was analyzed, and the underlying mechanism was investigated. Treating cells with only small Au-NPs (2 nm) significantly enhanced He-LTP-induced apoptosis. In comparison, 40 nm and 100 nm Au-NPs failed to enhance cell death. Mechanistically, the synergistic enhancement was due to 2 nm Au-NPs-induced decrease in intracellular glutathione, which led to the generation of intracellular ROS. The combined treatment significantly enhanced the intracellular ROS formation and apoptosis. These findings indicate that metal NPs are the potential modifiers of biological effects of LTP to regulate intracellular ROS. |
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