Bulletin of the American Physical Society
70th Annual Gaseous Electronics Conference
Volume 62, Number 10
Monday–Friday, November 6–10, 2017; Pittsburgh, Pennsylvania
Session TR3: Biomedical Plasmas |
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Chair: Mounir Larossi, Old Dominion University Room: Oakmont Junior Ballroom |
Thursday, November 9, 2017 4:00PM - 4:30PM |
TR3.00001: Therapy and decontamination by plasma sources Invited Speaker: Klaus-Dieter Weltmann Nowadays cold atmospheric pressure plasmas (CAP) with temperatures below 40 \textdegree C offer new therapeutic possibilities. The interest in using plasma sources operating at atmospheric pressure is of increasing importance in life sciences. Plasma Medicine includes already established or applications in progress of gas discharge plasmas, such as the antimicrobial treatment (decontamination) of medical devices, pharmaceutical products or packaging materials as well as surface modification of implants (functionalization, coating) and furthermore different therapeutic applications. Consequently, practical application of CAP in medicine is currently focused on dermatology as well as plastic and aesthetic surgery and oncology. \newline Much basic research is still required to fully understand the complex mechanisms concerning the effects of plasmas on living cells and living tissue for avoiding side effects and identifying systematic treatment options. Whereby topics such as clean air, clean water and clean food are gaining more and more attention. \newline Nevertheless, future application in other fields are expected. Besides treatment of teeth and implants with different purposes, in dentistry also wounds as well as infective and inflammatory diseases of gum and oral mucosa will be targets of CAP application. \newline An overview about present plasma based devices in medicine in different application areas will be given followed by actual results achieved for wound healing and tumor treatment in different hospitals.\\ \\Main Author: Klaus-Dieter Weltmann from Leibniz Institute for Plasma Science and Technology (INP Greifswald). In collaboration with: Thomas von Woedtke, Torsten Gerling, J\"urgen Kolb from Leibniz Institute for Plasma Science and Technology (INP Greifswald) and Hans-Robert Metelmann from Greifswald University Medicine, Greifswald, Germany [Preview Abstract] |
Thursday, November 9, 2017 4:30PM - 4:45PM |
TR3.00002: Multi-pulse operation of an atmospheric-pressure plasma jet onto a reactive liquid layer. Seth A. Norberg, Guy Parsey, Stuart Daudlin, Amanda M. Lietz, Eric Johnsen, Mark J. Kushner Medical applications of non-thermal atmospheric plasmas are predominantly associated with modification of a liquid environment surrounding tissue. The plasma-induced biological response results from reactive oxygen and nitrogen species (RONS), either produced in the liquid-phase or transferred through solvation from the gas-phase, reaching the target tissue. In atmospheric pressure plasma jets (APPJs), the pulse repetition frequency (PRF) and proximity of the ionization wave to the liquid surface, controlled indirectly through pulse duration, stand out as parameters that can be adjusted to achieve the desired outcome. An APPJ incident onto tissue with an intervening reactive liquid layer was simulated using a 2-dimenstional plasma hydrodynamics model while varying the PRF and plasma-liquid proximity. A high PRF allows for plasma activated species to co-exist in the gas phase for multiple pulses resulting in increasing densities of N$_{\mathrm{x}}$O$_{\mathrm{y\thinspace }}$and hence aqueous NO$_{\mathrm{3}}^{\mathrm{-}}$ and ONOO$^{\mathrm{-}}$. Conversely, a lower PRF minimizes inter-pulse reactions in the gas phase which consume ROS, resulting in a higher ROS fluence to the underlying tissue. The altered reaction pathways are not linear with the PRF as aqueous H$_{\mathrm{2}}$O$_{\mathrm{2}}$ fluences to the tissue are not sensitive to PRF variation. Significantly different ratios of fluences of reactive species to the tissue occur when comparing touching and non-touching interaction of the plasma-plume and liquid surface. [Preview Abstract] |
Thursday, November 9, 2017 4:45PM - 5:00PM |
TR3.00003: Effects of Gas Temperature in Plasma Layer on RONS generation in Array-type Dielectric Barrier Discharge at Atmospheric Pressure Sung-Young Yoon, Changho Yi, Sngheum Eom, Seungil Park, Seong Bong Kim, Seungmin Ryu, Sung Jae Yoo In this work, we demonstrate the changing of the major plasma generating species under the fixed discharge gas composition. The atmospheric pressure plasmas in the atmosphere are able to produce various reactive oxygen and nitrogen species (RONS). The O3 and NOx are representative RONS. Since the influences of these species show different influences on the organisms, it is necessary to change the plasma produced species depending on the treatment targets. We generate the plasma under ambient airflow using the array-type dielectric barrier discharge (DBD) electrode. The plasma generated species with flow rates are monitored using the FTIR. It was found that main generation transits from O3 to NOx as the flow rate increased. As a result of comparative analysis by measuring the gas temperature in discharge and the electrode surface temperature using OES and IR, it was found that the gas temperature of the discharge layer is an important factor to regulate the discharger species. Acknowledgments -- This study was supported by R{\&}D Program of `Plasma Advanced Technology for Agriculture and Food (Plasma Farming)' through the National Fusion Research Institute of Korea (NFRI) funded by the Government funds. [Preview Abstract] |
Thursday, November 9, 2017 5:00PM - 5:30PM |
TR3.00004: Plasma jets and electric fields delivery on targets relevant for biomedical applications Invited Speaker: Eric Robert The study of plasma jets operating in free jet mode and on conductive targets relevant for biomedical applications is discussed. The simultaneous diagnostics of helium metastable through laser absorption, electric field (EF) with an electro-optic probe and current appears as a unique approach to get deep insights on the mechanisms triggered when primary ionization wave (IW), driving the plasma jet propagation, impacts the target. Secondary IWs, back and forth travelling from the plasma jet powered electrode and the grounded target, is measured and may result, depending on the operating parameters of the device, in the transition to a glow like discharge. In such situation, huge enhancement of reactive species production is triggered in connection with significant increase of current flowing through the target. This study allow for a better analysis of the plasma jet delivery on target relevant for biomedical applications and open up opportunities to control reactive species concentration and current amplitude in such experiments. These experimental results are in good agreement with modeling work recently published by group of M.J. Kushner (University of Michigan) on the plasma jet touching or not targets of various natures. The second aspect of the study deals with the characterization of both the amplitude and the topology of the transient EF generated in the vicinity of the plasma jets. Time resolved longitudinal and radial EF, with respect to the jet propagation axis, having amplitudes ranging from a few to a few tens of kV/cm have been measured. There also a good agreement is achieved with modeling data from the group of A. Bourdon (LPP laboratory) which allow extending this diagnostics to region where experimental analysis is hard or disturbing with our probe. It is probably worth considering such intense EF with respect to their potential impact on biological samples. [Preview Abstract] |
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