Bulletin of the American Physical Society
68th Annual Gaseous Electronics Conference/9th International Conference on Reactive Plasmas/33rd Symposium on Plasma Processing
Volume 60, Number 9
Monday–Friday, October 12–16, 2015; Honolulu, Hawaii
Session BM1: Challenge of Plasma Science towards Future Medicine Workshop II |
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Chair: Mounir Laroussi, Old Dominion University Room: 301 B |
Monday, October 12, 2015 3:30PM - 4:00PM |
BM1.00001: Systematization of the Mechanism by Which Plasma Irradiation Causes Cell Growth and Tumor Cell Death Invited Speaker: Nobuyuki Shimizu New methods and technologies have improved minimally invasive surgical treatment and saved numerous patients. Recently, plasma irradiation has been demonstrated that might be useful in medical field and the plasma irradiation device is expected to become practically applicable. Mild plasma coagulator showed some advantages such as hemostasis and adhesion reduction in experimental animal model, but the mechanism of plasma irradiation remains unclear. Our study group aim to clarify the mechanism of plasma irradiation effects, mainly focusing on oxidative stress using cultured cell lines and small animal model. First, a study using cultured cell lines showed that the culture medium that was activated by plasma irradiation (we called this kind of medium as ``PAM'' -plasma activated medium-) induced tumor cell death. Although this effect was mainly found to be due to hydrogen peroxide, the remaining portion was considered as the specific effect of the plasma irradiation and we are now studying focusing on this effect. Second, we established a mouse intra-peritoneal adhesion model and checked biological reaction that occurred in the adhesion part. Histopathological study showed inflammatory cells infiltration into adhesion part and the expression of PTX3 that might involve tissue repair around adhesion part. We also confirmed that cytokines IL-6 and IL-10 might be useful as a marker of adhesion formation in this model. Applying ``PAM'' or mild plasma irradiation in this model, we examine the effects of plasma on inflamed cells. The samples in these experiments would be applied to targeted proteomics analysis, and we aim to demonstrate the systematization of the cell’s reaction by plasma irradiation. [Preview Abstract] |
Monday, October 12, 2015 4:00PM - 4:30PM |
BM1.00002: Gas Flow and Electric Field Characterization in Plasma Jets for Biomedical Applications: From Single Jet to Multi Jet Arrays Invited Speaker: Eric Robert This work reports first on time-resolved measurement of longitudinal and radial electric fields (EF) associated with plasma propagation in dielectric capillaries. Plasma propagation occurs in a region where longitudinal EF exists ahead the ionization front position revealed from plasma emission with ICCD measurement. The ionization front propagation induces the sudden rise of a radial EF component. Both of these EF components have a few kV/cm in amplitude for helium or neon plasmas. Their amplitude is kept almost constant along a few tens of cm long capillary. The key role of the voltage pulse polarity and the drastic impact of the presence of a target in front of the plasma jet are discussed from Schlieren images. All these experimental measurements are in excellent agreement with model calculations which are used to infer EF data on capillary axis. EF diagnostics in the plasma plume in the free jet mode but also in contact with various targets is proposed. The combination of intense transient EF, both of ns and µs duration, together with significant transient reactive species generation during plasma jet treatments may be reconsidered. Typical EF amplitudes likely to induce electrostimulation, electroporation are indeed probably achieved in many in vivo protocols. Stimulation of tissue oxygenation, blood flow rate modulation and more recently immune system triggering may be examples where EF could play a significant role. The second part of this work is dedicated to the development of multi jets, using two different setups, based on a single plasma source. Plasma splitting in dielectric tubes drilled with sub millimetric orifices, but also plasma transfer across metallic tubes equipped with such orifices are analyzed from ICCD imaging and time resolved EF measurements. This allows for the design of plasma jet arrays but also emphasizes the necessity to account for voltage pulse polarity, target potential status, consecutive helium flow modulation and electrostatic influence between the produced secondary jets. The development of plasma arrays based on combination of plasma splitting within dielectric tubes and plasma transfer across metallic tube is reported leading to the generation of tens of secondary jets from a single PG device, i.e a single DBD reactor flushed with 2 l/mn of helium. [Preview Abstract] |
Monday, October 12, 2015 4:30PM - 5:00PM |
BM1.00003: Mechanisms of Plasma Therapeutics Invited Speaker: David Graves In this talk, I address research directed towards biomedical applications of atmospheric pressure plasma such as sterilization, surgery, wound healing and anti-cancer therapy. The field has seen remarkable growth in the last 3-5 years, but the mechanisms responsible for the biomedical effects have remained mysterious. It is known that plasmas readily create reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS and RNS (or RONS), in addition to a suite of other radical and non-radical reactive species, are essential actors in an important sub-field of aerobic biology termed ``redox'' (or oxidation-reduction) biology. It is postulated that cold atmospheric plasma (CAP) can trigger a therapeutic shielding response in tissue in part by creating a time- and space-localized, burst-like form of oxy-nitrosative stress on near-surface exposed cells through the flux of plasma-generated RONS. RONS-exposed surface layers of cells communicate to the deeper levels of tissue via a form of the ``bystander effect,'' similar to responses to other forms of cell stress. In this proposed model of CAP therapeutics, the plasma stimulates a cellular survival mechanism through which aerobic organisms shield themselves from infection and other challenges. [Preview Abstract] |
Monday, October 12, 2015 5:00PM - 5:05PM |
BM1.00004: Closing remarks |
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