Bulletin of the American Physical Society
63rd Annual Gaseous Electronics Conference and 7th International Conference on Reactive Plasmas
Volume 55, Number 7
Monday–Friday, October 4–8, 2010; Paris, France
Session BT4: Biological and Biomedical Applications of Plasmas I |
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Chair: Uros Cvelbar, Academic and Research Network of Slovenia Room: Petit Amphitheatre |
Tuesday, October 5, 2010 8:30AM - 9:00AM |
BT4.00001: Low energy electron collisions of relevance to biological radiation damage Invited Speaker: The interaction of low energy electrons with DNA is known to cause strand breaks and lead to its damage. This process occurs fundamentally through dissociative electron attachment initiated via the formation of a temporary negative ion. Many experimental studies of electron scattering from DNA strands and from its constituents, both in gas and condensed phase, have contributed to the understanding of this process. The electron-rich nature of the DNA building blocks make them difficult targets to study computationally. Most of the work carried out so far concentrates on elastic scattering from nucleobases, deoxyribose, phosphoric acid as well as deoxynucleosides and deoxynucleotides. Calculations for electronically inelastic processes are very scarce. We will present theoretical results both for isolated molecules and small molecular cluster that aim at elucidating how low energy electrons interact with DNA and other molecules present in the cell (for example, water), how this is affected by hydrogen bonding and what role is played by inelastic channels. [Preview Abstract] |
Tuesday, October 5, 2010 9:00AM - 9:30AM |
BT4.00002: Plasma Biomedicine: Modelings and Experiments on Cancer Treatment, Tooth Bleaching, and Decontamination Invited Speaker: Non-thermal atmospheric pressure plasmas have attracted great interests and been widely used in biomedical applications to interact with living tissue, cell, and bacteria. Gold nanoparticles conjugated with anti-FAK antibody have been introduced to cancerous cells to enhance selective killing of cancerous and normal cells, and the mechanism of cell apoptosis induced by plasma has been investigated [1,2]. Tooth exposed to helium plasma jet with hydrogen peroxide or alike has become brighter and the production of hydroxyl radicals decomposed from hydrogen peroxide have been enhanced by plasma exposure [3]. Sterilization by non-thermal plasma devices and the global and PIC modelings of these plasmas will also be presented. \\[4pt] [1] G. C. Kim, et al., ``Air plasma coupled with antibody-conjugated nanoparticles: a new weapon against cancer,'' \textit{J. Phys. D: Appl. Phys.} 42, 032005 (2009); \textit{Plasma Medicine} (to appear); \textit{Europhysics News} 40/2, 14 (2009).\\[0pt] [2] G. J. Kim, et al., ``DNA damage and mitochondria dysfunction in cell apoptosis induced by nonthermal air plasma,'' \textit{Appl. Phys. Lett.} \textbf{96}, 021502 (2010). \\[0pt] [3] H. W. Lee, et al., ``Tooth bleaching with nonthermal atmospheric pressure plasma,'' \textit{J. Endod.} \textbf{35}, 587 (2009); Plasma Proc. {\&} Polymers 7, 274 (2010). [Preview Abstract] |
Tuesday, October 5, 2010 9:30AM - 9:45AM |
BT4.00003: Hollow Optical Fiber-Based Microplasma for Single Cell-Level Cancer Therapy Jae Young Kim, John Ballato, Paul Foy, Thomas Hawkins, Yanzhang Wei, Jinhua Li, Sung-O Kim While atmospheric pressure plasmas have been used in cancer therapies the size of the delivery systems precludes single cell treatments. Here, a highly flexible hollow-core optical fiber-based microplasma device is shown to treat individual tumor cells. It is observed that the microplasma not only induced apoptosis in cultured murine cells in a dose-dependent manner, but also, in some experimental conditions, selectively destroyed cultured tumor cells with no harm to cultured fibroblasts as indicated by an Annex V apoptosis assay. The induction of apoptosis in cultured murine tumor cells is confirmed further using an in situ apoptosis assay, which also showed a well-defined boundary between plasma-treated and non-treated areas. This work enables new directed cancer therapies based on highly flexible and precise hollow optical fiber-based plasma medicine and offers a unique path to understanding plasma-induced tumor cell apoptosis. [Preview Abstract] |
Tuesday, October 5, 2010 9:45AM - 10:00AM |
BT4.00004: Control of ROS and RNS in air surface micro-discharge for antisepsis and sterilization Yukinori Sakiyama, Tetsuji Shimizu, David Graves, Gregor Morfill Ambient gas plasma is a promising technology in various areas of medicine. We have developed a plasma antisepsis and sterilization device based on a surface micro-discharge in air at atmospheric pressure. ROS (reactive oxygen species) and RNS (reactive nitrogen species) are thought to play crucial roles in sterilization. The ultimate goal of this project is to develop numerical models for a better understanding of plasma-biomaterial interaction and for optimization of the device efficiency. Here, we focus on the modeling of plasma chemistry of the plasma sterilization device in humid air. Our model is based on a zero-dimensional plasma fluid model with the local field approximation. The model includes 48 species and 630 reactions. Electron density and electric field are given as input parameters from our experiments. Surface reactions are included. Initial simulation results indicate many reactive species are generated in discharge region, including O2*, H2O2, N2O, NO2, NO, O, OH, NO, and HO2. In the presentation, our simulation results will be compared with experimental measurements. We will also propose methods to control the ROS and RNS to optimize the device efficiency. [Preview Abstract] |
Tuesday, October 5, 2010 10:00AM - 10:15AM |
BT4.00005: Pulsed spark discharge plasma characterization and its biological applications Danil Dobrynin, Andrey Starikovskiy, Gary Friedman, Alexander Fridman Recently, cold pin-to-hole spark discharge (PHD) plasma was reported to be successfully applied for the treatment of a human patient with complicated ulcerous eyelid wounds. Such treatment was essentially salvatory for patient's life: PHD plasma was shown to have ``healing'' and bactericidal effects, while other conventional medical treatments did not have an effect. In order to understand which components of spark plasma (and associated mechanisms) caused the observed biological effects, the discharge characterization is required. This will also allow optimization of the discharge and possibly finding new medical applications. Microsecond PHD spark discharge development was investigated both experimentally and numerically. Formation of hot jet from the discharge gap has been observed and characterized. This jet is an effective mechanism of active species production in the discharge zone and they transport to the treated surface. Numerical model includes discharge and gasdynamic parts. Formation of main species was calculated and efficiency of the pin-hole discharge cell configuration for biomedical applications was analyzed. [Preview Abstract] |
Tuesday, October 5, 2010 10:15AM - 10:30AM |
BT4.00006: Prospects of dielectric barrier discharge (DBD) in medical application: Investigation through plasma characterization P. Rajasekaran, P. Mertmann, N. Bibinov, P. Awakowicz, D. Wandke, W. Vioel A DBD device capable of generating plasma on human body is studied for medical therapy of skin. The device comprises of a ceramic-covered electrode driven by a 13 kV pulsed power supply at 300 Hz trigger frequency. When breakdown conditions are satisfied, discharge is ignited in ambient air between the working electrode and the treated substrate, which serves as the opposite electrode in this case. Biologically-reactive molecules like nitric oxide (NO) and ozone are produced due to plasma-chemical processes in the active plasma region. These molecules can be useful for treatment of wounds and skin diseases. The flux of NO and ozone reaching the treated surface is determined with the help of plasma characterization. We characterize the plasma through determination of gas temperature and plasma parameters like electron density and electron velocity distribution function (EVDF), using experimental methods namely optical emission spectroscopy (OES), current-voltage measurements, microphotography and numerical simulation. Using the determined parameters, flux of NO, ozone and UV photons reaching the treated surface is simulated. The simulation results are compared with other sources applied in similar medical application. [Preview Abstract] |
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