Bulletin of the American Physical Society
2023 Spring Meeting of the APS Eastern Great Lakes Section
Volume 68, Number 5
Saturday, April 1, 2023; Oakland University, Rochester, Michigan
Session K01: Poster Session & Snacks (3:30pm-5:00pm EDT)
3:30 PM,
Saturday, April 1, 2023
Oakland University HHB
Room: 4050
Chair: Michael Crescimanno, Department of Physics, Youngstown State University
Abstract: K01.00016 : Development of PTOA in Rabbits post ACL tear via µMRI Study*
Presenter:
Austin Tetmeyer
(Oakland University)
Authors:
Austin Tetmeyer
(Oakland University)
Yang Xia
(Oakland University)
Farid Badar
(Oakland university)
Hannah Mantebea
(oakland university)
Amanveer Singh
(oakland university)
The difference in observed T2 values between the injured and non-injured (I vs. NI) was measured in this study, providing useful insight into the development of OA following an ACL tear injury.
Specimens of articular cartilage (n = 6 for 2 weeks, n = 6 for 6 weeks, n=6 for 14 weeks) still attached to the underlying bone from a humerus (shoulder joint) or femur (knee joint) were imaged using µMRI. Quantitative µMRI data with a pixel resolution of 11.7-13.2 µm/pixel showed differences between the sets of injury development times as well as a relationship between time post injury and T2 relaxation values.
Ongoing work for the project involves further analysis of a section of specimens subjected to a high impact on the surface of the joint as opposed to the same ACL tear as the rest of the specimens. Additionally, polar light microscopy (PLM) is being conducted with histological samples of all of the specimens.
*This project is funded by an NIH R01 grant (AR 069047)
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