Bulletin of the American Physical Society
2023 Spring Meeting of the APS Eastern Great Lakes Section
Volume 68, Number 5
Saturday, April 1, 2023; Oakland University, Rochester, Michigan
Session K01: Poster Session & Snacks (3:30pm-5:00pm EDT)
3:30 PM,
Saturday, April 1, 2023
Oakland University HHB
Room: 4050
Chair: Michael Crescimanno, Department of Physics, Youngstown State University
Abstract: K01.00014 : Imaging characteristics of rabbit femoral cartilage in the early post-trauma by µMRI and PLM*
Presenter:
Hannah Mantebea
(oakland university)
Authors:
Hannah Mantebea
(oakland university)
Yang Xia
(Oakland University)
Farid Badar
(Oakland university)
Gabrielle Abdelmessih
(oakland university)
Amanveer Singh
(oakland university)
Sebastian Talia
(oakland university)
Kevin Baker
(kevin.Baker@beaumont.org)
Michael Newton
(Beaumont hospital)
METHODS: A total of 12 female New Zealand rabbits were equally grouped into two sets: 0 weeks and 6 weeks. In both groups, the femur of one knee from each animal was impacted through a surgical approach and the contralateral knee was kept intact. For the 0-week group, the animal was sacrificed immediately after the impact, and a cartilage bone plug of 2 x 3 x 2 mm was excised from the femur at the impact site and imaged using µMRI at a resolution of 11.7µm/pixel. Histological sections were made on the cartilage tissue and imaged using Polarized Light Microscopy (PLM) at a resolution of 1µm/pixel. The 6-week group had the animal sacrificed six weeks after the one-time impact and similar imaging procedures were performed.
RESULTS: T2 relaxation values generated from the µMRI with the surface of the cartilage oriented at 55˚ to the external magnetic field Bo showed an increase in the 6-week group’s bulk cartilage samples, with a statistical difference of p-value = 0.06 . The major contribution towards this T2 increase came from the superficial (SZ) and transitional zone (TZ). The optical Angular and Retardation images and depth-dependent profiles generated from the PLM, which demonstrates a reduced SZ in the 6-weeks of impacted cartilage.
CONCLUSION: An increase in T2 values in 6 weeks of cartilage samples explains the increase in hydration in the early progression of PTOA. Reduction in the superficial zone thickness from the angular and retardation measurements demonstrates subtle disruption of the cartilage surface.
*This project is funded by an NIH R01 grant (AR 069047).
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