Bulletin of the American Physical Society
2023 Fall Meeting of the APS Eastern Great Lakes Section
Friday–Saturday, October 20–21, 2023; Cleveland State University, Cleveland, Ohio
Session F01: Poster Session
5:30 PM,
Friday, October 20, 2023
Cleveland State University
Room: Fenn Tower 303
Abstract: F01.00026 : A New Disease Detect and Capture Device: CAPGLO
Presenter:
Patrick M Deluca
(Case Western Reserve University)
Authors:
Patrick M Deluca
(Case Western Reserve University)
Robert J Deissler
(Case Western Reserve University)
Charlotte L Bimson
(Case Western Reserve University)
Robert W Brown
(Case Western Reserve University)
We describe tests carried out with representative, sufficiently sophisticated cells. We coat insect cells as fluorescent functionalized groups and image them using a small digital microscope. With the ability to locate the individual cells and attach micron-sized magnetic particles to them, even a single cell can be guided into a tiny pocket of a sample cuvette with a gradient magnetic field. A digital microscope combined with a filter for fluorescence reading can be used to prove the cell was indeed captured.
The device, with a 3D-printed cuvette, fluorescent dye, and MPs coated with a binding agent, was used to test our ability to detect the target cells. The gradient field draws the resultant MP-cell clusters into the collection region of the sample holder. The “glowing” signal seen in the collection region indicated the presence of captured cells. The cells were then imaged with an inexpensive microscope and counted with software.
We thus have a working prototype: a new low-cost fluorescent digital camera/filter/laser detection system for both capturing and counting the recovered cells. Current work is directed toward comparing the sensitivity levels with the different cancer concentrations in the human body. The total prototype cost including the cuvette is ~$300 for the system, which strongly suggests a (much) lower unit cost for large-scale manufacturing.
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