Bulletin of the American Physical Society
2023 Fall Meeting of the APS Eastern Great Lakes Section
Friday–Saturday, October 20–21, 2023; Cleveland State University, Cleveland, Ohio
Session C01: Invited Speaker Dr. Fangwei Si
3:00 PM–3:45 PM,
Friday, October 20, 2023
Cleveland State University
Room: Fenn Tower 303
Chair: Ulrich Zurcher, Cleveland State University
Abstract: C01.00001 : How bacteria organize cellular space at the microscale and the nanoscale
3:00 PM–3:45 PM
Presenter:
Fangwei Si
(Carnegie Mellon University)
Author:
Fangwei Si
(Carnegie Mellon University)
spatially organized to dictate cellular scale behaviors. In this talk, I will discuss how bacteria as simple living systems organize membrane space at the microscale and the nanoscale to possibly optimize cell fitness. The organization of the cell membrane connects to its physiological state via a combination of physical, chemical, and biological processes. We are trying to disentangle this complexity by testing a fundamental hypothesis suggested by our preliminary observations: the membrane real-estate hypothesis – the cytoplasmic membrane is so packed with proteins that the cell needs to fine-tune the density, composition, and organization of the membrane proteins for optimizing cell fitness. To better test this idea, we quantify and manipulate the density, composition, and spatial organization of membrane proteins and examine their effects on physiological states such as growth, adaptation, and cell death. We will use these results to test physical models that connect membrane properties to cell physiology. The outcomes from this hypothesis-testing can help us bridge cellular organization and physiology and understand better cellular adaptation, a branch of knowledge that can be extended to studying other higher organisms.
Follow Us |
Engage
Become an APS Member |
My APS
Renew Membership |
Information for |
About APSThe American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics. |
© 2024 American Physical Society
| All rights reserved | Terms of Use
| Contact Us
Headquarters
1 Physics Ellipse, College Park, MD 20740-3844
(301) 209-3200
Editorial Office
100 Motor Pkwy, Suite 110, Hauppauge, NY 11788
(631) 591-4000
Office of Public Affairs
529 14th St NW, Suite 1050, Washington, D.C. 20045-2001
(202) 662-8700