Bulletin of the American Physical Society
64th Annual Meeting of the APS Division of Plasma Physics
Volume 67, Number 15
Monday–Friday, October 17–21, 2022; Spokane, Washington
Session JO08: Laser-Plasma Ion Accelerators
2:00 PM–4:48 PM,
Tuesday, October 18, 2022
Room: 402 ABC
Chair: Robbie Scott, STFC Rutherford Appleton Laboratory
Abstract: JO08.00001 : Tumor irradiation in mice with a laser-accelerated proton beam
2:00 PM–2:12 PM
Presenter:
Florian-Emanuel Brack
(Helmholtz-Zentrum Dresden-Rossendorf, 01328 Dresden, Germany)
Authors:
Florian-Emanuel Brack
(Helmholtz-Zentrum Dresden-Rossendorf, 01328 Dresden, Germany)
Florian Kroll
(Helmholtz-Zentrum Dresden-Rossendorf, 01328 Dresden, Germany)
Josefine Metzkes-Ng
(Helmholtz-Zentrum Dresden-Rossendorf, 01328 Dresden, Germany)
Jörg Pawelke
(OncoRay – National Center for Radiation Research in Oncology, Dresden, Germany)
Marvin Reimold
(Helmholtz-Zentrum Dresden-Rossendorf, 01328 Dresden, Germany)
Ulrich Schramm
(Helmholtz-Zentrum Dresden-Rossendorf, 01328 Dresden, Germany)
Tim Ziegler
(Helmholtz-Zentrum Dresden-Rossendorf, 01328 Dresden, Germany)
Karl Zeil
(Helmholtz-Zentrum Dresden-Rossendorf, 01328 Dresden, Germany)
Elke Beyreuther
(Helmholtz-Zentrum Dresden-Rossendorf, 01328 Dresden, Germany)
Current developments at the high-power laser source Draco operated at Helmholtz-Zentrum Dresden-Rossendorf enabled the production of polychromatic proton beams with energies greater than 60 MeV with unprecedented stability and long-term reliability. These achievements allowed to successfully conduct the first radiobiological in vivo study using a laser-driven proton source. This pilot irradiation study was performed on human tumors in a mouse model, showing the concerted preparation of mice and laser accelerator, the dose-controlled, tumor-conform irradiation using a laser-driven as well as a clinical reference proton source, and the radiobiological evaluation of irradiated and unirradiated mice for radiation-induced tumor growth delay. The prescribed homogeneous dose of 4 Gy was precisely delivered at the laser-driven source. The results demonstrate a complete laser-driven proton research platform for diverse user-specific small animal models, able to deliver tunable single-shot doses up to around 20 Gy to millimeter-scale volumes on nanosecond time scales, equivalent to around 109 Gy/s, spatially homogenized and tailored to the sample. The platform provides a unique infrastructure for translational research with protons at ultra-high dose rate.
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