Bulletin of the American Physical Society
76th Annual Meeting of the Division of Fluid Dynamics
Sunday–Tuesday, November 19–21, 2023; Washington, DC
Session ZC14: Biofluids: Small Vessels and Microcirculation II
12:50 PM–2:47 PM,
Tuesday, November 21, 2023
Room: 144AB
Chair: Arif Masud, University of Illinois
Abstract: ZC14.00009 : Red blood cell lingering modulates hematocrit distribution in the microcirculation
2:34 PM–2:47 PM
Presenter:
Christian Wagner
(Univ des Saarlandes)
Authors:
Christian Wagner
(Univ des Saarlandes)
Alexis Darras
(Univ des Saarlandes)
Timm Krueger
(University of Edinburgh)
Qi Zhou
(University of Edinburgh)
Miguel Bernabeu
(University of Edinburgh)
To explore these deviations, we employed a combination of in vivo experiments and in silico simulations, focusing on the microscopic behavior of RBC lingering. We introduce a novel method to quantify the extent of cell lingering at highly confined capillary-level bifurcations, demonstrating its correlation with deviations from established empirical predictions by Pries et al. Moreover, we examine how bifurcation geometry and cell membrane rigidity influence RBC lingering. Notably, we find that rigid cells exhibit reduced lingering compared to softer ones.
Our findings emphasize the importance of considering RBC lingering as a significant mechanism in the study of microcirculatory abnormalities associated with diseases like malaria and sickle-cell disease. Additionally, this research sheds light on how pathological conditions, such as thrombosis, tumors, and aneurysms, can alter the microvascular networks. By comprehensively understanding the role of RBC lingering, we can enhance our understanding of how abnormal RBC rigidity affects microcirculatory blood flow and contribute to the development of targeted interventions for various vascular disorders.
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