Bulletin of the American Physical Society
76th Annual Meeting of the Division of Fluid Dynamics
Sunday–Tuesday, November 19–21, 2023; Washington, DC
Session ZC14: Biofluids: Small Vessels and Microcirculation II
12:50 PM–2:47 PM,
Tuesday, November 21, 2023
Room: 144AB
Chair: Arif Masud, University of Illinois
Abstract: ZC14.00007 : Title: Predictions of microvascular leak from an anatomically correct mouse GI tract*
2:08 PM–2:21 PM
Presenter:
Serenity J Sudbrock
(Liberty University)
Authors:
Serenity J Sudbrock
(Liberty University)
Anthony J Bauer
(Liberty University)
Wayne Strasser
(Liberty University)
Prior research resulted in the discovery of a novel RX protein proven to cause cell death in injected mice via hyper vasoconstriction. This project seeks to lay further groundwork for trauma research and ultimately a solution to the failure of the major organs in humans after experiencing major trauma on the battlefield or otherwise. This was achieved by creating a CAD-modeled section of the microvasculature in the GI tract of a mouse. The necessary data and images were previously attained through Electron Scanning Microscopy (ESM) analysis of the intestinal mucosa. Based on acquired blood flow and pressure data as well as measured lumen diameter response data to the RX protein, an average base pressure, flow rate and scale were chosen. This idealized model was compared to simulations in which the base values were construed by the vasoconstriction response of both venules and arterioles and an induced jejunal microvascular leak. Then, graphical techniques related to pressure and blood flow changes provide further data for continued research in this field.
*Liberty University
Follow Us |
Engage
Become an APS Member |
My APS
Renew Membership |
Information for |
About APSThe American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics. |
© 2024 American Physical Society
| All rights reserved | Terms of Use
| Contact Us
Headquarters
1 Physics Ellipse, College Park, MD 20740-3844
(301) 209-3200
Editorial Office
100 Motor Pkwy, Suite 110, Hauppauge, NY 11788
(631) 591-4000
Office of Public Affairs
529 14th St NW, Suite 1050, Washington, D.C. 20045-2001
(202) 662-8700