Bulletin of the American Physical Society
76th Annual Meeting of the Division of Fluid Dynamics
Sunday–Tuesday, November 19–21, 2023; Washington, DC
Session X10: Biofluids: Respiratory Flows I
8:00 AM–10:36 AM,
Tuesday, November 21, 2023
Room: 140B
Chair: Brett Meyers, Purdue University
Abstract: X10.00009 : In silico modeling of asymmetric airways: in health and in disease*
9:44 AM–9:57 AM
Presenter:
Mahesh V Panchagnula
(Indian Institute of Technology Madras)
Authors:
DEBJIT KUNDU
(Indian Institute of Technology Madras)
Mahesh V Panchagnula
(Indian Institute of Technology Madras)
Our research explores the structure-function relationships in the airways through in-silico methods of varying complexities. We show that natural asymmetry of the human lung enhances particle filtration through tracheobronchial deposition by around 5%, while other parameters like gas exchange surface area, volume occupied by the airways and resistance to airflow deviate by more than 10% of their optimal value. Through our investigations of regional deposition in the lung, we show how asymmetry, particle size, breathing rate and bronchoconstriction (a common marker of several lung diseases) influence the distribution of deposition in the lung. On one hand, these insights shed light on airborne infection mechanisms. On the other hand, they guide precise dosage determination of medications as well as the choice and design of delivery devices.
*The authors are grateful to Indian Institute of Technology Madras and Prime Minister's Research Fellows (PMRF) scheme, Ministry of Education, Government of India (project no. SB21221950AMPMRF008445) for the financial support provided by them.
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