Bulletin of the American Physical Society
76th Annual Meeting of the Division of Fluid Dynamics
Sunday–Tuesday, November 19–21, 2023; Washington, DC
Session T34: Micro/Nano scale Flows: Devices and Applications
4:25 PM–6:09 PM,
Monday, November 20, 2023
Room: 201
Chair: Axel Guenther, University of Toronto
Abstract: T34.00002 : Collagen Tube-Based Model to Study Small Airway Collapse-Reopening Dynamics*
4:38 PM–4:51 PM
Presenter:
Axel Guenther
(University of Toronto)
Authors:
Axel Guenther
(University of Toronto)
Wuyang Gao
(University of Toronto)
Collaboration:
We acknowledge contributions by Emma Graham and Ruud A. Veldhuizen from Western University.
Relationships between the transmural pressure and the tube cross section favorably compare with previous studies performed in synthetic tubes. We further explore conditions relevant to ventilation induced lung injury and captured both the overdistension as well as the collapse and reopening scenarios. Our findings suggest the former to not significantly affect cell viability while the latter lead to acute cell death. We observed that increasing expiratory airflow resistance resulted in a slower collapse velocity and reduced severity of cell injury. The integrity of the epithelial barrier was compromised during repetitive collapse and reopening cycles but remained intact during overdistension. Our extracellular matrix based small airway model provides a valuable and adaptable platform for studying lung physiology, particularly related to conditions relevant in ventilation-induced lung injury. The ability to replicate the complex biomechanical microenvironment of the respiratory system enhances our understanding of small airway epithelial function and disease progression.
The presented approach enhances our understanding of lung physiology, especially for ventilation-induced lung injury, while holding promise for broad application in organ-on-a-chip models for different tubular tissues.
*CRAFT Project Award, NSERC Discovery Award (AG)
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