Bulletin of the American Physical Society
76th Annual Meeting of the Division of Fluid Dynamics
Sunday–Tuesday, November 19–21, 2023; Washington, DC
Session L09: Biofluids: Medical Devices II
8:00 AM–10:36 AM,
Monday, November 20, 2023
Room: 140A
Chair: Brent Craven, U.S. Food and Drug Administration
Abstract: L09.00008 : Sensitivity of platelet activation in an ECMO pump due to different modelling approaches
9:31 AM–9:44 AM
Presenter:
Francesco Fiusco
(KTH Royal institute of technology)
Authors:
Francesco Fiusco
(KTH Royal institute of technology)
Lars Mikael Broman
(ECMO Centre Karolinska, Karolinska Institutet, Solna, Sweden)
Lisa Prahl Wittberg
(KTH Royal institute of technology)
Mechanical stresses play a role in platelet activation, assessed as platelet activation state (PAS). CFD can be a valuable tool to investigate effects of circuit component flow structures on thrombogenic properties in different scenarios. However, a proper assessment of the influence of boundary conditions and modelling approach is needed to characterize the sensitivity of the results due to modelling choices employed in the particle tracking. In this work, Lagrangian Particle Tracking (LPT) was used where 100’000 spherical particles, representing platelets, were injected in an ECMO blood pump to record stress history and compute their activation state. The LPT was carried out as a post-processing step on a time-resolved flow field produced using Star-CCM+. Blood was treated as a Newtonian fluid. Considering particle inertia, Newton’s 2nd law was used to compute particle velocity. In this work, drag, lift and pressure gradients were considered. The impact of these forces on platelet trajectories and activation state will be studied for different particle sizes and densities.
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