Bulletin of the American Physical Society
76th Annual Meeting of the Division of Fluid Dynamics
Sunday–Tuesday, November 19–21, 2023; Washington, DC
Session L08: Biofluids: Large Vessels and Arteries II
8:00 AM–10:36 AM,
Monday, November 20, 2023
Room: 103B
Chair: Qianhong Wu, Villanova University
Abstract: L08.00009 : Evaluating the Sensitivity of Coronary Artery Hemodynamics to Anatomical Changes in Angles, Branch Positions, and Diameter Ratios
9:44 AM–9:57 AM
Presenter:
Arnav Garcha
(Carnegie Mellon University)
Authors:
Arnav Garcha
(Carnegie Mellon University)
Noelia Grande GutiƩrrez
(Carnegie Mellon University)
To address these limitations, we quantified hemodynamic sensitivity to changes in bifurcation angles, positions, and diameter ratios in left-coronary arteries (LCA). We implemented an automated workflow in Simvascular to generate synthetic 3D LCA geometries based on data from angiographic studies [3, 4, 5]. The hemodynamic simulations considered rigid arterial walls and used physiological inlet waveforms and specialized coronary outlet conditions. We computed WSS and normalized low WSS areas (ALWSS) at bifurcations and branches in 75 LCA models.
At the proximal LCA bifurcation, position had a more significant effect than angle on ALWSS (R = -0.97, p < 0.0001 v.s. R = -0.62, p < 0.01). Distal ALWSS increased with upstream bifurcation positions (R = -0.78, p < 0.01). Diameter asymmetry at the bifurcation led to higher ALWSS in the smaller branch (p < 0.01).
In conclusion, vascular structure variations had a significant effect on coronary hemodynamics. In particular, proximal bifurcations and high diameter ratios increased ALWSS, potentially indicating greater plaque formation risk.
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