Bulletin of the American Physical Society
75th Annual Meeting of the Division of Fluid Dynamics
Volume 67, Number 19
Sunday–Tuesday, November 20–22, 2022; Indiana Convention Center, Indianapolis, Indiana.
Session G07: Medical Devices I |
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Chair: Anne Staples, Virginia Tech Room: 134 |
Sunday, November 20, 2022 3:00PM - 3:13PM |
G07.00001: A slim, powerless microfluidic patch-pump for transdermal drug delivery Shuyu Zhang, Adaliah M Dunya, Cayla Katz, Jessica Prisbe, Rafael V Davalos, Anne E Staples The delivery of many pharmaceuticals and biologicals remains a challenge. A significant portion of these materials can be delivered orally, yet others, especially macromolecular drugs that are degraded during first-pass metabolism, must rely on transdermal injection. For insulin delivery, conventional syringe injections and battery-powered pumps are associated with non-adherence due injection site pain and inconvenience. Using soft lithography and stereolithographic 3D printing techniques, we have developed multilayer microfluidic devices based on the principles of insect respiration that can be actuated by the wearer's arterial pulse and can act as painless drug delivery vehicles when coupled with 3D-printed microneedle arrays. Pressurized air that mimicked the human radial pulse was used to drive the flow at 12 different actuation frequencies and 7 different pressures. We found that the flow rate of fluid increased with increasing actuation frequency for some device designs but decreased (ideal for insulin delivery) for others. The flow rate generally exhibited a positive relationship with the actuation pressure. We have assembled these microfluidic devices, together with 3D-printed, hollow microneedle arrays, into integrated prototype patch-pumps for drug delivery. |
Sunday, November 20, 2022 3:13PM - 3:26PM |
G07.00002: Design and development of prototype blister-packs for intradermal injection of viscous solutions Chase Zitterkopf, Jeremy O Marston We investigate the feasibility and prototype fabrication of novel blister-pack devices for intradermal and subcutaneous injections. The devices are designed to deliver both low and high-viscosity solutions (potentially nucleic acid vaccines) using hollow micro-needles embedded in a sealed felxible casing, which is pre-filled with a fixed volume. |
Sunday, November 20, 2022 3:26PM - 3:39PM |
G07.00003: Flow measurement of the environmental test chamber for Closed System Transfer Device test protocol Ziyu Wei, Kathryn E Nelson, Zhongwang Dou A closed system transfer device (CSTD) should be used when cytotoxic or hazardous drugs are prepared and administered in any clinical setting. In order to make sure the CSTD is working correctly, a performance test (leakage test) in an environmental test chamber needs to be conducted. A draft of this Performance Test Protocol for CSTD has been developed by the National Institute for Occupational Safety and Health (NIOSH), and it is open for improvements. This study aims to fill in some critical missing information in this test protocol by conducting flow field measurements in the environmental test chamber. Specifically: (1) Flow rate and duration during air purge of the chamber; (2) Location and flow rate of air sampling pump during CSTD operation; and (3) duration of air sampling after CSTD operation. This study provides valuable information on the effectiveness of this CSTD performance test protocol and possible ways to improve this protocol. |
Sunday, November 20, 2022 3:39PM - 3:52PM |
G07.00004: Development of High-sensitivity Paper-based Detection Device with Hydrophobic Polymer Pattern Youngkwang Moon, Hyeokgyun Moon, Junhyuck Chang, Jung Heon Lee, Jinkee Lee Typical diagnostic devices include real-time polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA) and so on. These diagnostic devices can precisely diagnose, but point-of-care and rapid diagnoses are difficult. Therefore, there is a keen interest in developing paper-based diagnostic devices capable of point-of-care and rapid diagnosis. The paper-based diagnostic devices are used in various areas, such as diagnosis of the disease and testing drugs or toxic chemicals. Most paper-based devices are composed of hydrophilic cellulose or nitrocellulose membrane, and a general example of the device is a lateral flow immunoassay (LFIA) strip. However, paper-based diagnostic devices are known to have a very low sensitivity which is a problem. To solve this drawback, we designed a new type of paper-based diagnostic device using a polymer pattern. A very simple method is used to imprint a polymer pattern onto the device, and by concentrating the detection material (Molecular beacon, MB) in the pattern, we could fabricate a highly sensitive paper diagnostic device, having high sensitivity similar to the ELISA. The developed paper-based diagnostic device is expected to be used in various fields including livestock and human diseases detection. |
Sunday, November 20, 2022 3:52PM - 4:05PM |
G07.00005: Rotational diffusometry with integrated LAMP method for rapid and highly sensitive pathogenic nucleic acid detection Dhrubajyoti Das, Han-Sheng Chuang Nucleic acid amplification tests (NAATs), based on polymerase chain reaction (PCR) have gained massive popularity in molecular diagnostics, due to their high sensitivity and accuracy. However, the operational complexity and requirement of expensive thermocyclers hinder the use of PCR for rapid onsite screening. Loop-mediated isothermal amplification (LAMP) is an alternative and attractive nucleic acid amplification technique that is accurate with high sensitivity and specificity. Therefore, to carry out a rapid, sensitive, and accurate NAAT, we combine LAMP with rotational diffusometry enabled by functionalized Janus particles. Here we use the SARS-CoV-2 cDNA targeting nsp-2 gene in a recombinant plasmid as a proof of concept for COVID-19 diagnostics. According to the Stokes-Einstein-Debye equation, the rotational diffusivity is inversely proportional to the liquid viscosity. Therefore, a positive LAMP will rapidly increase the sample viscosity, resulting a slower rotational diffusion of the Janus particles. A limit of detection of 70 ag/µL was achieved in just 10 min with a sample volume as low as 2 µL. Furthermore, the LAMP assay was successfully developed on an open-well microfluidic platform. |
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