Bulletin of the American Physical Society
71st Annual Meeting of the APS Division of Fluid Dynamics
Volume 63, Number 13
Sunday–Tuesday, November 18–20, 2018; Atlanta, Georgia
Session N39: Invited Talk: The Hydrodynamics of Intracellular Macromolecular Motion
10:40 AM–11:15 AM,
Tuesday, November 20, 2018
Georgia World Congress Center
Room: Ballroom 3/4
Chair: Gary Leal, University of California Santa Barbara
Abstract ID: BAPS.2018.DFD.N39.1
Abstract: N39.00001 : The hydrodynamics of intracellular macromolecular motion
10:40 AM–11:15 AM
Presenter:
Roseanna N Zia
(Stanford University)
Author:
Roseanna N Zia
(Stanford University)
Many representations of cellular behavior rely on abstractions that do not account for how macromolecules are organized and move within the crowded, watery cell milieu. For example, linear algebra- and differential equation-based models typically do not represent biomolecules or their spatial positioning and motion. For many questions in biology and medicine these simpler models have been sufficient. However, fundamental gaps in understanding of many cell functions persist; physics may provide a bridge to close such gaps. I will discuss our progress in developing computational and theoretical tools to model spherically confined colloidal suspensions, as a simple model cell, so that biomolecules and their interactions can be physically represented, individually and explicitly. By developing a more robust and fundamentally well-grounded physics model for how macromolecules interact within cells we can contribute to a more physically complete representation of living matter. A primary challenge in models of confined colloidal suspensions is the accurate and efficient representation of many-body hydrodynamic interactions, Brownian motion, and the enclosure itself. To this end, we developed a new “Cellular Stokesian dynamics” framework that accounts for spherically confined many-body hydrodynamic and lubrication interactions, Brownian motion, and active transport. Utilizing this model, we studied diffusion, cooperative motion, and self-organization with confinement and crowding levels representative of a cell interior. I will discuss the qualitative influence of hydrodynamics, confinement and crowding on transport behavior, as well as the consequences of neglecting such influences. Connections to underlying structure are made, and implications for cellular function are discussed.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2018.DFD.N39.1
Follow Us |
Engage
Become an APS Member |
My APS
Renew Membership |
Information for |
About APSThe American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics. |
© 2025 American Physical Society
| All rights reserved | Terms of Use
| Contact Us
Headquarters
1 Physics Ellipse, College Park, MD 20740-3844
(301) 209-3200
Editorial Office
100 Motor Pkwy, Suite 110, Hauppauge, NY 11788
(631) 591-4000
Office of Public Affairs
529 14th St NW, Suite 1050, Washington, D.C. 20045-2001
(202) 662-8700