Bulletin of the American Physical Society
71st Annual Meeting of the APS Division of Fluid Dynamics
Volume 63, Number 13
Sunday–Tuesday, November 18–20, 2018; Atlanta, Georgia
Session KP1: Poster Session (3:20-4:05pm)
3:20 PM,
Monday, November 19, 2018
Georgia World Congress Center
Room: Level 1, Exhibit Hall B2 by the GFM videos
Abstract ID: BAPS.2018.DFD.KP1.2
Abstract: KP1.00002 : Understanding Collective Function of Platelets During Blood Clot Retraction*
Presenter:
Yueyi Sun
(Georgia Institute of Technology)
Authors:
Yueyi Sun
(Georgia Institute of Technology)
David Myers
(Georgia Institute of Technology, Emory University)
Wilbur Lam
(Georgia Institute of Technology, Emory University)
Alexander Alexeev
(Georgia Institute of Technology)
Blood clots formed during the wound healing process essential for restoring normal blood circulation. Disorders associated with blood clotting can lead to highly dangerous conditions resulting in bleeding, stroke or heart attack. Furthermore, undesired blood clots can lead to thrombosis diseases. It is therefore important to understand the physics governing blood clotting for developing efficient treatment of these disorders. During clot retraction, microscopic platelets extend filopodia to surrounding fibrin filaments to contract the fibrin mesh resulting in macroscale volume changes of the clot. We construct an experimentally informed mesoscopic computational model to examine the micromechanics of clot retraction. The model allows us to probe the effects of filipodia properties and platelet heterogeneity on fibrin clot dynamics. Results indicate that platelet heterogeneity associated with differences in platelet activation times is essential for achieving efficient clot retraction.
*NSF CAREER Award DMR-1255288
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2018.DFD.KP1.2
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