Bulletin of the American Physical Society
71st Annual Meeting of the APS Division of Fluid Dynamics
Volume 63, Number 13
Sunday–Tuesday, November 18–20, 2018; Atlanta, Georgia
Session G18: Biological fluid dynamics: Aneurysms and Blood Clots
10:35 AM–12:45 PM,
Monday, November 19, 2018
Georgia World Congress Center
Room: B305
Chair: Jung-Hee Seo, Johns Hopkins University
Abstract ID: BAPS.2018.DFD.G18.2
Abstract: G18.00002 : Lagrangian tracking of platelet residence time and shear history to enhance understanding of the hemodynamics of endovascular stenting in cerebral aneurysms
10:48 AM–11:01 AM
Presenter:
Laurel Morgan Miller Marsh
(Department of Mechanical Engineering, University of Washington, Seattle, WA, USA)
Authors:
Laurel Morgan Miller Marsh
(Department of Mechanical Engineering, University of Washington, Seattle, WA, USA)
Michael C Barbour
(Department of Mechanical Engineering, University of Washington, Seattle, WA, USA)
Fanette Chassagne
(Department of Mechanical Engineering, University of Washington, Seattle, WA, USA)
Venkat Keshav Chivukula
(Department of Mechanical Engineering, University of Washington, Seattle, WA, USA)
Cory M. Kelly
(Department of Neurological Surgery, University of Washington, Seattle, WA, USA)
Samuel Levy
(Department of Neurological Surgery, University of Washington, Seattle, WA, USA)
Michael R Levitt
(Department of Mechanical Engineering, University of Washington, Seattle, WA, USA, Department of Neurological Surgery, University of Washington, Seattle, WA, USA)
Louis J. Kim
(Department of Neurological Surgery, University of Washington, Seattle, WA, USA, Department of Radiology, University of Washington, Seattle, WA, USA)
Alberto Osuna Aliseda
(Department of Mechanical Engineering, University of Washington, Seattle, WA, USA, Department of Neurological Surgery, University of Washington, Seattle, WA, USA)
Flow-diverting stents (FDS) promote the formation of a stable thrombus within the aneurysmal sac, isolating its wall from mechanical stresses and preventing rupture. Platelet activation, a necessary mechanism for thrombus formation, is known to respond to biomechanical stimuli, particularly to the platelets’ shear stress exposure and residence time in the aneurysmal sac. Currently, there is no accurate prediction of FDS outcomes. Eulerian computational fluid dynamic studies of aneurysmal flow have searched for predictors of endovascular treatment outcome; however, the hemodynamics of thrombus formation cannot be fully understood without considering the platelets’ Lagrangian microenvironment and their mechanics-triggered activation. Lagrangian analysis of the fluid mechanics in the aneurysmal vasculature provides novel metrics by tracking the platelets’ residence time (RT) and shear history (SH) and combining them into a treatment success potential score. The comparison of such parameters for patient-specific cases, pre- and post-treatment, will be presented. The methodology proposed for developing platelet-based Lagrangian tracking studies into accurate predictors of endovascular stenting outcome will be described in detail.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2018.DFD.G18.2
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