Bulletin of the American Physical Society
71st Annual Meeting of the APS Division of Fluid Dynamics
Volume 63, Number 13
Sunday–Tuesday, November 18–20, 2018; Atlanta, Georgia
Session E36: Porous Media Flows in Biological Contexts |
Hide Abstracts |
Chair: Boris Stoeber, University of British Columbia Room: Georgia World Congress Center B408 |
Sunday, November 18, 2018 5:10PM - 5:23PM |
E36.00001: On the characterization of interstitial fluid flow in the skeletal muscle Qiuyun Wang, Michael Schenk, Liyun Wang, Qianhong Wu In this paper, we report a comprehensive experimental and theoretical approach to examine the interstitial fluid flow in skeletal muscles under external compression. The project aims to understand the transport phenomena within the three-dimensional and highly hierarchical muscular matrices, which is of physiological importance for the muscle-bone cross-talk. Gastrocnemius muscles from mouse and cow were harvested, hydrated, and subjected to indentation creep tests using a custom-designed indentation device. A theoretical model was developed considering the non-uniform compression of the muscle sample in the vertical direction. The key parameter of the theoretical model, the Darcy permeability, was obtained using a histology-structure-based theoretical approach, where an effective permeability was proposed. The theoretical model was used to predict the time-dependent interstitial pressure distribution inside the skeletal muscle. This study, providing the first quantitative estimation of the interstitial fluid pressure distribution in the skeletal muscle, is of significant importance for understanding the biophysics of the muscle-bone cross-talk, leading to new treatment strategy of musculoskeletal diseases and defects. |
Sunday, November 18, 2018 5:23PM - 5:36PM |
E36.00002: A mixture theory based degradation model for poro-elastic nerve guides and its ALE-FEM implementation Priyanka Patki, Francesco Costanzo Therapies in peripheral nerve injury repairs require that regrowing axonal projections be guided to their targets, which is currently done via nerve autografts. The latter have severe shortcomings such as scarcity of donor sites and possible neuroma development. The development of TENG (Tissue Engineered Nerve Guide) is hence crucial to said therapies. TENGs must be biocompatible, biodegradable, and bioresorbable to avoid repeated surgeries. Degradation rates must match axonal regrowth rates. TENGs must maintain mechanical integrity and function throughout degradation. At the same time, they must have the right transport properties to deliver nutrients and growth factors. Design and optimization of TENGs therefore requires a predictive capability that accounts for the coupling between the material's chemo-mechanical-transport behaviours. Here we present a degradation theory for CUPE (cross linked urethane-doped polyester elastomers) TENGs. The development is based on mixture theory and accounts for reaction, diffusion and convection of a fluid phase and of additional solutes moving within a degrading solid skeleton. In addition to theory formulation we also present numerical implementation via an ALE (arbitrary Lagrangian Eulerian) finite element method. |
Sunday, November 18, 2018 5:36PM - 5:49PM |
E36.00003: Real-time visualization of fluid absorption by skin tissue following injection using optical coherence tomography Pranav Shrestha, Boris Stoeber The skin is a potential site for delivering drugs such as vaccines and insulin, and novel devices such as microneedles can target the upper layers of the skin for effective drug delivery. Fluid flow into a deformable porous medium like skin tissue deforms the soft porous matrix, and consequently changes macroscopic parameters such as porosity and permeability. A major challenge in observing fluid flow into biological tissue is the highly optically scattering nature of tissue. Optical coherence tomography (OCT) is a promising biomedical imaging modality that provides cross-sectional images of the skin tissue in real-time with micron-scale resolution. We will present flow-induced tissue deformations captured by OCT during the injection of fluid at different viscosities and pressures into freshly excised porcine skin tissue through hollow microneedles. These tissue deformations are correlated with microfluidic sensor data of fluid flow-rate and pressure recorded during the injections. The experimental data can be used to extract displacement/strain fields in the tissue, and macroscopic skin properties such as permeability. |
Sunday, November 18, 2018 5:49PM - 6:02PM |
E36.00004: Abstract Withdrawn
|
Sunday, November 18, 2018 6:02PM - 6:15PM |
E36.00005: Theoretical and Experimental Study of Transient Squeezing Flow in a Thin Porous Gap Ji Lang, Rungun Nathan, Qianhong Wu In this study, we report a novel theoretical and experimental approach to examine transient squeezing flow in a thin gap filled with highly porous media. This problem is inspired by such biological phenomena as the cerebral spinal fluid flow in the subarachnoid space. It is featured by low Reynolds number, low Strouhal number and low Brinkman number. Thus, convective fluid acceleration is negligible and the pressure response is governed by the local acceleration, the viscous force and the Darcy resistance. By using a Laplace transform method, we have analytically solved the problem, which shows that the flow starts with an inviscid limit and as time goes on, it reaches steady flow governed by the Brinkman equation. A novel experimental setup, containing a piston instrumented with a displacement sensor and a pressure transducer, was established to examine the validity of the theoretical solution. Excellent agreement between the theory and the experimental data was obtained, validating the theoretical approach. The study presented herein examining the fundamental mechanisms of transient fluid flow in a soft porous media will have a significant impact on biological and industrial applications.
|
Sunday, November 18, 2018 6:15PM - 6:28PM |
E36.00006: A two-phase flow model for a soft poroelastic drop suspended in a Stokes flow Yuan-nan Young, Yoichiro Mori, Michael John Miksis In this work a two-phase flow model is constructed to study the combined effects of interfacial slip, permeability and elasticity of the porous skeleton inside a viscous drop under simple linear flows. This two-phase flow model describes a viscous fluid filling a deformable elastic skeleton inside a drop whose interface deforms according to the balance of traction on the interface. When the viscous dissipation of the interior porous flow is negligible (compared to the friction between the fluid and the skeleton), the two-phase flow is reduced to a poroelastic Darcy fluid. At the interface between such an interior poroelastic fluid and an exterior Stokesian fluid, both slip and permeability are taken into account. The permeating flow induces dissipation that depends on the elastic stress of the interior solid. By exploring the interfacial slip, permeability and interior elasticity various flow patterns are found at equilibrium of these slightly deformed poroelastic drops. These results shed light on the rheology of a suspension of poroelastic spherical particles, and give insight to possible flow patterns of a system of self-propelling swimmers with porous flow (such as intracellular cytosol) inside. |
Follow Us |
Engage
Become an APS Member |
My APS
Renew Membership |
Information for |
About APSThe American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics. |
© 2025 American Physical Society
| All rights reserved | Terms of Use
| Contact Us
Headquarters
1 Physics Ellipse, College Park, MD 20740-3844
(301) 209-3200
Editorial Office
100 Motor Pkwy, Suite 110, Hauppauge, NY 11788
(631) 591-4000
Office of Public Affairs
529 14th St NW, Suite 1050, Washington, D.C. 20045-2001
(202) 662-8700