Bulletin of the American Physical Society
71st Annual Meeting of the APS Division of Fluid Dynamics
Volume 63, Number 13
Sunday–Tuesday, November 18–20, 2018; Atlanta, Georgia
Session E18: Biological fluid dynamics: Blood Flow in Organs
5:10 PM–6:28 PM,
Sunday, November 18, 2018
Georgia World Congress Center
Room: B305
Chair: Cyrus Aidun, Georgia Institute of Technology
Abstract ID: BAPS.2018.DFD.E18.4
Abstract: E18.00004 : A biphasic computational model of the mechanics of the blood-perfused liver*
5:49 PM–6:02 PM
Presenter:
Yi-Jui Chang
(Mechanical & Aerospace Engineering, Univ of California - Los Angeles)
Authors:
Yi-Jui Chang
(Mechanical & Aerospace Engineering, Univ of California - Los Angeles)
Daniel Canuto
(Mechanical & Aerospace Engineering, Univ of California - Los Angeles)
Kwitae Chong
(Mechanical & Aerospace Engineering, Univ of California - Los Angeles)
Jeff D. Eldredge
(Mechanical & Aerospace Engineering, Univ of California - Los Angeles)
Joseph M. Teran
(Mathematics, Univ of California - Los Angeles)
Peyman Benharash
(Surgery, Univ of California - Los Angeles)
Erik Dutson
(Surgery, Univ of California - Los Angeles)
Modeling the mechanics of injured soft tissues is important for medical applications. The current study focuses on the liver and aims to simulate its material and hemo-dynamic response. The liver is considered as a dynamic poro-hyperelastic material with blood-filled voids. A biphasic formulation—effectively, a generalization of Darcy’s law---is utilized, treating the phases as occupying fractions of the same volume. A Stokes-like friction force and a pressure that penalizes deviations from volume fractions summing to unity serve as the interaction force between solid and liquid phases. The conservation equations are discretized by the method of Smoothed Particle Hydrodynamics. Inflow conditions are obtained from a systemic cardiovascular model with regulatory response, automatically adapting to hemorrhage and other disturbances. Simulations of the mechanics under baseline conditions will be demonstrated. Ongoing progress in modeling the liver under injuries and surgical conditions will be discussed.
*We gratefully acknowledge the support of the US Army Medical Research Acquisition Activity (grant no. W81XWH-15-1-0147) and the US Office of Naval Research (grant no. N00014-13-C-0357).
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2018.DFD.E18.4
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