3:45 PM–5:45 PM, Thursday, November 8, 2007
Scarritt-Bennett Center - Laskey Great Hall
Chair: Shane Hutson, Vanderbilt University
Abstract ID: BAPS.2007.SES.EA.4
5:15 PM–5:45 PM
Jennifer Zallen
(Sloan-Kettering Institute)
The elongated body axis is a characteristic feature of many multicellular animals. Axis elongation occurs largely through cell rearrangements that are coordinated across a large cell population and driven by an asymmetric distribution of cytoskeletal and junctional proteins [1]. To visualize cellular dynamics during this process, we performed time-lapse confocal imaging of cell behavior in the Drosophila embryo. These studies revealed that rearranging cells display a steady increase in topological disorder that is accompanied by the formation of transient structures where 5-11 cells meet [2,3]. These multicellular rosettes form and resolve in a directional fashion to produce a local change in the aspect ratio of the cellular assembly, contributing to an overall change in tissue structure. We propose that higher-order rosette structures link local cell interactions to global tissue reorganization during morphogenesis. [1] J. Zallen and E. Wieschaus, Developmental Cell 6, 343 (2004). [2] J. Zallen and R. Zallen, J. Phys.: Condens. Matter 16, S5073 (2004). [3] J. Blankenship et al., Developmental Cell 11, 459 (2006).
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2007.SES.EA.4