Bulletin of the American Physical Society
2023 APS March Meeting
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session T44: Optical methods in therapy and imaging
11:30 AM–2:06 PM,
Thursday, March 9, 2023
Room: Room 316
Sponsoring
Units:
GMED DBIO
Chair: Robert H. Austin; Matija Milanic, University of Ljubljana
Abstract: T44.00001 : Microstructure-Dependent Optical Properties of Doped Spinel Oxide Nanosystems*
11:30 AM–11:42 AM
Presenter:
David Beke
(Stavropoulos Center for Complex Quantum Matter, Department o)
Authors:
David Beke
(Stavropoulos Center for Complex Quantum Matter, Department o)
Adam Gali
(Wigner Research Centre for Physics)
Mátyás M Rudolf
(Wigner Research Centre for Physics)
Bence G Markus
(University of Notre Dame)
Doped spinel crystals show long-lasting emissions (LLP) in the visible and near-IR regions that can be activated by X-ray or UV-visible light. Such properties make this material a promising candidate for background-free deep-tissue bioimaging, photodynamic or photon-induced therapy (PIT), optical sensing, and many other applications. The optical properties, however, are highly dependent on the dopant environment and the nature of the trap states responsible for the LLP. Annealing changes the defect structures of Cr and the trap states and the strength of the energy transfer between the different Cr defects and significantly affects the optical properties. We found crystal field decrease at low temperatures caused by quasi-melted pseudocrystalline surface, making them temperature sensitive, an order of magnitude increase in the photon yield upon X-ray or UV illumination, and temperature-dependent LLP. The outcome of the fundamental research on the defect structure is that at optimum annealing conditions, activating the IR700 photoactive dye used in PIT, with X-ray excitation, or by the LLP that promises PIT for deep-seated or embedded tumors or other diseases is possible.
*This study was supported by the János Bolyai Scholarship of the Hungarian Academy of Sciences, UNKP-20 New National Excellence program, project no. TKP2021-NVA-04 provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund (NKFIH), financed under the TKP2021-NVA funding scheme, the Quantum Information National Laboratory sponsored by the Ministry for Innovation and Technology of Hungary via NKFIH. This research was supported by Grant No. VEKOP-2.3.3-15-2016-00002 of the European Structural and Investment Funds. B.G.M. and F.S. acknowledge the support of the NKFIH Grant No. 137852. The research reported in this paper and carried out at BME has been supported by the NKFIH Fund (TKP2021) based on the charter of bolster issued by the NKFIH Office under the auspices of the Ministry for Innovation and Technology.
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