Bulletin of the American Physical Society
2023 APS March Meeting
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session S11: Collective Behaviors in Biology I
8:00 AM–11:00 AM,
Thursday, March 9, 2023
Room: Room 203
Sponsoring
Unit:
DBIO
Chair: Andrew Mugler, University of Pittsburgh
Abstract: S11.00011 : Cooperative T4 Phage Resistance in E. coli*
10:24 AM–10:36 AM
Presenter:
Krisztina Nagy
(Hungarian Acad. of Science)
Authors:
Robert H Austin
(Princeton University)
Krisztina Nagy
(Hungarian Acad. of Science)
Trung V Phan
(Princeton University)
Ryan Morris
(School of Physics & Astronomy, University of Edinburgh, Edinburgh, Scotland)
Julia Bos
(Institute Pasteur)
Peter Galajda
(Hungarian Academy Science)
But in the years following this work we have learned that Lamarck is not so easily dismissed, and we now know that there are many ways for organisms from bacteria to man to acquire heritable phenotype changes upon transient exposure to stress. We have show in a previous publication that stress gradients imposed over a metapopulation of weakly interacting communities can greatly increase the rate at which de novo evolved resistance the mutagenic antibiotic ciproflaxen. This begs the question: can a similar application of fundamental theories of evolution in small interconnected populations also be used to accelerate the {em de novo} emergence of phage resistance in E. coli? We do not aim to disprove the classic experiments of Delbruck and Luria of course, they are correct as implemented. But we do wish to show those experiments were incomplete and we show that indeed rapid de novo emergence to phage can occur upon exposure to phage.
*Austin, RH was supported by the NSF through the Center for the362Physics of Biological Function (PHY-1734030).
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