Bulletin of the American Physical Society
2023 APS March Meeting
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session N00: Poster Session II (11am-2pm PST)
11:00 AM,
Wednesday, March 8, 2023
Room: Exhibit Hall (Forum Ballroom)
Sponsoring
Unit:
APS
Abstract: N00.00282 : Molecular Mechanisms of Lipid-Induced Amyloid Fibril Formation from Global Fitting of Kinetic Models.
Presenter:
Alisdair Stevenson
(ETH Zurich)
Author:
Alisdair Stevenson
(ETH Zurich)
to building an understanding and the potential control of protein aggregation disorders, such as
Alzheimer's and Parkinson's diseases. A fundamental challenge in achieving this is the complexity of
the aggregation reaction network itself, which makes it difficult to analyse kinetic data of protein
aggregation in terms of the underlying mechanisms. Here we present a theoretical framework, based
on chemical reaction kinetics and global fitting, that allows the interpretation of quantitative
experimental measurements of α-synuclein aggregation on lipid membranes, a process linked to
Parkinson’s disease. These results provide a framework for modelling amyloid forming systems with
lipid-dependent interactions and has the potential to guide the rational design of small-molecule
inhibitors of α-synuclein aggregation.
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