Bulletin of the American Physical Society
2023 APS March Meeting
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session N00: Poster Session II (11am-2pm PST)
11:00 AM,
Wednesday, March 8, 2023
Room: Exhibit Hall (Forum Ballroom)
Sponsoring
Unit:
APS
Abstract: N00.00280 : Mutations on WFYY motif alters the PrimPol activity: Structural insights from atomistic MD simulations*
Presenter:
Vipin k Mishra
(iit bombay)
Author:
Vipin k Mishra
(iit bombay)
Collaborations:
Vipin Kumar Mishra, Sruthi Sudhakar, Pradeepkuamr P. I.
at stalled replication forks. The WFYY motif of PrimPol was previously reported to play an
essential role in stabilizing the incoming 3′-nucleotide. The W87G and Y90D mutations
significantly reduced the primase and polymerase activity of PrimPol. We have performed
microsecond scale molecular dynamics on wildtype, W87G, F88L, Y89D, and Y90D complexes
to investigate the structural implications of the single point mutations in PrimPol polymerase
activity. This study points towards the possible changes in the interdomain communication in
the PrimPol enzyme associated with single point mutations in the conserved motifs of the
enzyme.
*IIT Bombay, India
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