Bulletin of the American Physical Society
2023 APS March Meeting
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session K02: Binding and Assembly of Proteins on Membranes
3:00 PM–6:00 PM,
Tuesday, March 7, 2023
Room: Room 125
Sponsoring
Units:
GSNP DSOFT DBIO
Chair: Ehssan Nazockdast, University of North Carolina at Chapel H; Christopher Edelmaier
Abstract: K02.00012 : Antibody binding regulates the dynamics of the membrane-bound prion protein*
5:36 PM–5:48 PM
Presenter:
Ioana M Ilie
(University of Amsterdam)
Authors:
Ioana M Ilie
(University of Amsterdam)
Marco Bacci
(University of Zurich)
Andreas Vitalis
(University of Zurich)
Amedeo Caflisch
(University of Zurich)
Here, we investigate the influence of the POM1 and POM6 antibodies on the flexibility and the interaction with the membrane of the mouse PrPC by molecular dynamics simulations. The results show that in the presence of any of the two antibodies, the flexibility of the globular domain increases everywhere except for the ß1-α1 loop in the POM1/PrPC complex, which is part of its epitope [1]. Additionally, the binding of the antibodies restricts the range of orientations of the globular domain with respect to the membrane, decreases the distance between both modules of PrPC and the membrane, and restricts the orientational disorder of the globular domain. Furthermore, the interactions of the flexible tail and globular domain are modulated differently by the two antibodies [2].
[1] ILIE & Caflisch, BBA-Proteins Proteom. 1870, 140827 (2022)
[2] ILIE et al. Biophys. J. 121, 2813 (2022)
*Peter und Traudl Engelhorn Foundation
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